重型病毒性肝炎与肝炎病原学关系的研究

对107例重型病毒性肝炎与肝炎病原学的关系进行了分析，结果显示：亚重肝病人HBV复制指标HBeAg、HBcAbIgM及HBV－DNA阳性率高于慢重肝，而慢重肝的HbeAb阳性率（54．2％）明显高于亚重肝（27．8％）。此外，还发现51．4％的重肝病人由单纯HBV感染引起，HBV合并HCV感染的重肝病人仅为23．4％。但是HBV与HCV重叠感染的重肝病人的病死率（52．0％）明显高于单纯HBV感染（29．1％）。以上结果提示：慢重肝可能主要由抗HBe阳性的HBV病毒株所引起。HBV与HCV的重叠感染能加重病人病情，增加病死率。

ANALYSIS OF THE RELATIONSHIP BETWEEN SEVERE VIRAL HEPATITIS AND PATHOGENETIC HEPATITIS VIRUS

The relationships between 107 cases of severe hepatitis and the hepatitis virus were analysed. The results show that the positive rates of the replicative markers of the hepatitus B virus, such as HBeAg, HBcAbIgM, and HBV DNA in subacute severe hepatitis were higher than those in chronic severe hepatitis. The positive rate of HBeAb, in chronic severe hepatitis (54. 2 % ) was much higher than that in subacute severe hepatitis (27. 8% ). The co-infec-tion of HBV and HCV was found in 23. 4 % of severe hepatitis patients. 51.4% of the severe hepatitis patients ill-nesses were caused by HBV infection only. However, the mortality rate of patients with severe hepatitis caused by the co-infection of HBV and HCV (52.0% ) was much higher than that of patients with severe hepatitis caused by HBV infection only (29. 1% ). Therefore, the results indicate that chronic severe hepatitis may he caused by HBeAb-positive HBV infection. The co-intection of HBV and HCV may increase the mortality rate of severe hepati-tis patients.