降压合剂对胰岛素抵抗高血压大鼠作用效应的实验研究

目的：观察降压合剂对胰岛素抵抗高血压大鼠（IRH）的作用效应。方法：雄性SD大鼠饲喂高糖高盐饲料造模，然后分组灌胃。观察各组体重（BW）、收缩压（SBP）、空腹血糖（FBG）、空腹血胰岛素（FINS）、胰岛素敏感性指数（ISI）、血脂及纤溶酶原活性（PLG）的变化。结果：造模阶段；造模各组SBP升高（P＜0．01），FBC无明显变化，FINS升高（P＜0．01），ISI下降（P＜0．01）；用药阶段：降压合剂可降低SBP，FBG，FINS及PLG；减少体重增长幅度，升高ISI及高密度脂蛋白胆固醇（HDL－C）（P＜0．01或P＜0．05）。结论：高糖高盐饲喂大鼠可产生高血压及胰岛素抵抗（IR）。降压合剂能降压、降糖、降血胰岛素、增加胰岛素敏感性指数、升高高密度脂蛋白胆固醇、降低纤溶酶原活性及减低体重。

Experimental Study on Effects of Jiang Ya He Ji on Insulin Resistance Hypertensive Rats

Objective:To investigate the effects of complexes of traditional Chinese medicines(Jiang Ya He Ji) on the insulin resistance hypertensive rats (IRH).Methods:Male Spraque-Darley rats were fed on high glucose and high salt diet. We observed the changes of body weight(BW),systolic blood pressure(SBP),fasting blood glucose(FBG),fasting blood insulin(FINS), insulin sensitivity index(ISI),blood lipid and plasminogen (PLG).Results:(1)Model-copied stage: In groups fed on high glucose and high salt diet, SBP and FINS increased ( P <0.01),and ISI decreased ( P <0.01).(2)Drug-used stage:Jiang Ya He Ji could reduce SBP,FBG,FINS,PLG and the scope of BW gain,and increase ISI and high-density lipoprotein-c (HDL-C) ( P <0.01 or 0.05).Conclusions:Hypertension and insulin resistance(IR) can be induced by high glucose and high salt diet.Jian Ya He Ji can reduce blood pressure,blood sugar,blood insulin,PLG,BW,and increase ISI,HDL-C.