Syndecan-1和乙酰肝素酶在肾癌中的表达和临床意义

目的探讨人肾癌中Syndecan-1和乙酰肝素酶蛋白的表达水平及其与肾癌发生、发展和转移的关系。方法应用免疫组化Envisiong两步法研究62例肾癌中Syndecan-1和乙酰肝素酶蛋白的表达水平。结果Syndecan-1在肾癌中阳性表达率为50％（31／62），其表达率与肿瘤的病理分级、临床分期和淋巴结转移有相关性（P〈0.01）。乙酰肝素酶在肾癌中阳性表达率为24．2％（15／62），其表达率与肿瘤的病理分级、临床分期和淋巴结转移有相关性（P〈0.01）。Syndecan-1和乙酰肝素酶蛋白表达呈正相关（P〈0.01），其共同表达率与肿瘤的病理分级、临床分期和淋巴结转移有相关性（P〈0.01）。结论Syndecan-1和乙酰肝素酶蛋白的共同表达能成为肾癌发生和发展的预后参数。

Expression and clinical significance of syndecan-1 and heparanase in renal cell carcinoma

Objective] To study the expression of syndecan-1 and heparanase protein in renal cell carcinoma and the relationship with development,progression and metastasis of carcinoma. Methods] Immunohistochemical technique was used to detect the expression of syndecan-1 and heparanase protein in 62 cases of renal cell carcinoma. Results] The positive protein expression of syndecan-1 was 50% (31/62). The syndecan-1 protein expression was correlated with the pathological type,clinical stage and lymph node metastasi...