| 槲皮素脂质体纳米粒对肝癌HepG2细胞生长的抑制作用 |
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| 引用本文： | 龙白,张阳德,张洋,刘祥彦.槲皮素脂质体纳米粒对肝癌HepG2细胞生长的抑制作用[J].中国现代医学杂志,2007,17(8):911-913. |
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| 作者姓名： | 龙白 张阳德 张洋 刘祥彦 |
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| 作者单位： | 中南大学,卫生部肝胆肠外科研究中心,湖南,长沙,410008 |
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| 摘 要： | 目的 比较槲皮素脂质体纳米粒化后对肝癌HepG2细胞的抑制作用是否优于纯槲皮素.方法 将不同浓度的槲皮素悬液与采用薄膜蒸发-高压均质法制备的槲皮素脂质体纳米粒,空白脂质体纳米粒槲皮素,加入到肝癌HepG2细胞悬液中进行培养,24h,48h后,加入MTT,观察细胞生长状况,分析抑制情况.结果 48h光密度值:同浓度的槲皮素脂质体纳米粒明显较槲皮素,空白脂质体纳米粒小,与5-Fu比较,明显较大,差异有显著性(P＜0.05).结论 在所使用的浓度范围内,槲皮素脂质体纳米粒对体外肝癌HepG2细胞生长的抑制作用更优于纯槲皮素.
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| 关 键 词： | HepG2细胞 槲皮素 空白脂质体纳米粒 槲皮素脂质体纳米粒 脂质体 |
| 文章编号： | 1005-8982(2007)08-0911-03 |
| 修稿时间： | 2006年10月20 |
Inhibitory effect of nanometer-granulated Quercetin liposome on growth of HepG2 cell |
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| LONG Bai,ZHANG Yang-de,ZHANG Yang,LIU Xiang-yan.Inhibitory effect of nanometer-granulated Quercetin liposome on growth of HepG2 cell[J].China Journal of Modern Medicine,2007,17(8):911-913. |
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| Authors: | LONG Bai ZHANG Yang-de ZHANG Yang LIU Xiang-yan |
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| Abstract: | Objective] To compare the inhibitory effects of the Quercetin and nanometer-granulated Quercetin liposome on HepG2 cell of liver cancer. Method] Quercetin liposome nanometer-granules and liposome nanometer-granules( By the means of film highly-pressured and evenly-textured)and Quercetin were respectively added into the HepG2 cell. After 24 hours or 48 hours, we observed the growth condition of cell with the MTT and analysed their inhibitory effects. Results] Discovery through the MTT: honour density function of 48 hours: honour density function of Quercetin liposome nanomete-granules is obviously lower than those of Quercetin, liposome nanomete-granules (P <0.05). Conclusion] The experiment showd that within the range of density applied, the inhibitory effect of Quercetin liposome nanomete-granules on HepG2 cell is better than that of Quercetin. |
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| Keywords: | HepG2 cell Quercetin nanomete-granules Quercetin liposome nanomete-granules liposome |
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