普通级、SPF级SD、Wistar大鼠血液生化常值的测定与比较

目的　测定普通级、SPF级SD大鼠 ,Wistar大鼠血液生化常值并进行比较。方法　日立 715 0全自动生化分析仪自动检测。结果　SPF级与普通级SD大鼠丙氨酸转氨酶、白蛋白、碱性磷酸酶、尿素氮、肌酐、铁、磷、镁、尿酸、低密度脂蛋白、胆汁酸差异有非常显著性 (P <0 0 1) ;SPF级与普通级Wistar大鼠总蛋白、白蛋白、碱性磷酸酶、总胆固醇、甘油三脂、尿素氮、乳酸脱氢酶、磷、镁、尿酸、高密度脂蛋白、胆汁酸 (P <0 0 1) ,低密度脂蛋白 (P <0 0 5 )差异有非常显著性。结论　不同微生物学环境对SD、Wistar大鼠血液生化常值有较大影响。

Comparison of Normal Values of Blood Examination in Conventional,SPF SD and Wistar Rats

Objective To measure and compare the normal values of blood routine examination in conventional,SPF SD and Wistar rats.Methods Hitachi-7150 was used in this experiment. Results The ALT,ALB,ALP,BUN,CRE,Fe,P,Mg,UA,LDL,PBA in conventional and SPF SD rats had very significant difference (P<0.01).The TP,ALB,ALP,CHO,TG,BUN,LDH,P,Mg,UA,HDL, PBA in conventional and SPF Wistar rats had very significant difference(P<0.01),the LDL had significant difference(P<0.05),the ALT,ABG,CRE,Fe,GLU,GOT had little difference(P>0.05). Conclusion Different microbiological background significantly affects the biochemical values of rats.