2型糖尿病大鼠糖代谢异常及仙人掌粉的干预效应

目的研究仙人掌粉对2型糖尿病（T2DM）大鼠血糖的影响及其机制。方法用高糖高脂饲料喂养加小剂量链脲佐菌素（STZ）注射造成2型糖尿病模型，然后将大鼠分成6组：正常对照组（N）喂普通饲料，糖尿病对照组（A）、苯乙双胍组（B）喂高糖高脂饲料，仙人掌大（C）、中（D）、小（E）剂量组喂仙人掌粉（9g/d只、6g/d只、3g/d只）和高糖高脂饲料，4周后测空腹血糖。结果C、D、E各组血糖值都有所降低（9.21±0.85、11.35±0.91、14.40±1.30），与实验前比较C、D组差异均有显著性（P〈0.01），与A组比较差异显著（P〈0.01），与B组比较差异不显著（P〉0.05）。结论仙人掌粉能够降低2型糖尿病大鼠血糖值，作为药食两用的野生植物具有极大的开发和利用价值。

Interventional Effect of Opuntia on the Blood Glucose Level in Type Ⅱ Diabetic Rats

Objective To study the effect of Opuntia on the blood glucose level in rat model of type II diabetes mellitus. Method Rat model of type II diabetes mellitus (DM) was eastablished with streptozotocin (STZ). 60 rats with DM were divided into six groups (10 rats each): normal control (N), DM control (A), PEDG (B), and low dose (E, fed with 3 g/d), moderate dose (D, fed with 6 g/d) and high dose (C, fed with 9 g/d) of Opuntia. Results The blood glucose levels in C (9.21 0.85), D (11.35 0.91) and E(14.40 1.30) groups were significantly decreased in comparison with that before Opuntia administration in groups C and D (P<0.01), and also significant difference compared with group A (P<0.01), but not with group B (P>0.05). Conclusion Opuntia may decrease the blood glucose level in rat model of type II diabetes mellitus, and is worth further studing on its clinical application.