药物安全性评价中毕格狗子宫组织病理学的比较医学意义

目的　探讨毕格狗子宫组织在药物安全性评价研究中的组织病理学特征。方法　用病理形态学方法 ,将子宫重量、子宫系数 (宫重 体重 )及子宫组织形态学作为主要观察指标 ,对 4组 (A、B、C、D) 4 3～ 74周龄雌性毕格狗 (每组各 8只动物 ) ,按不同实验时间 (春、夏、秋、冬四季 )处死进行组织病理学检查 ,比较分析各组检查结果。结果　A组与D组、B组与C组之间子宫系数均数差异有极显著性 (P <0 0 1)。结合子宫重量比较分析组织学观察结果表明 ,各组动物的子宫组织形态均显示出明显不同的动情周期特征 ,且这种特征与子宫重量和子宫系数具有明显的相关性。结论　非妊娠雌性毕格狗在用作药物安全性评价研究时 ,子宫组织受动情期的影响而呈现出明显的周期性变化 ,对子宫重量、子宫系数及子宫组织形态所出现的差异在进行毒理病理评价时必须作具体分析。

The Significance of Comparative Medicine on Uterus Histopathology of Beagle Dog In Drug Safety Assessment

Objective To explore the histopathological characterization of the female beagle dog's uterus in drug safety assessment. Methods\ As controls in studies performed at our laboratory to assess the drug safety, female beagle dogs aged 43-74 weeks were at random divided into four groups and eight in each group were killed in spring, summer, autumn and winter respectively. The histological structures of their uteri were analysed. Results\ Oestrus\|related changes in the histological structure of uterus and weight were observed. The differences between the uterus of the four groups, especially in uterus endomertrium and uterus glands, showed highly comparative medicine significance in drug safety studies. Conclusion\ The results suggested that when non\|pregnancy female beagle dogs were used in safety assessment studies, the toxicologic pathology evaluation of uterus should be correlated with the physiological factors of distinguishing spontaneous changes.