救心复脉注射液致突作用研究

本文用Ames实验、体外染色体畸变实验、微核试验对救心复脉注射液进行了致突变性研究。结果显示，救心复脉(Jiuxin Fumai，JXFM)注射液对TA97、RA98、TA100、TA102菌株无致突变性；体外细胞染色体畸变实验未引起CHO细胞染色体畸变，实验未引起CHO细胞染色体畸变率的升高；2．0g/kg、4．0/kg、8．0g/kg的救心复脉注射液对小鼠骨髓多染红细胞无诱发微核增加作用。实验结果表明，救心复脉注射液无致突变作用。

Studies on Mutagenicity of Jiuxin Fumai Injection

In this paper,the effect of mutagenicity of the Jiuxin Fumai Injection was investigated.The results showed that Jiuxin Fumai Injection did not induce positive mutation of strains TA 97 , TA 98 ,TA 100 and TA 102 in the Ames test.The rates of CHO chromosome aberration of Jiuxin Fumai Injection were negative range(<5%).The results of micronucleus assay of polychromatic erythrocytes in mice of Jiuxin Fumai Injection at 3 doses of 2.0 g/kg, 4.0 g/kg, 8.0 g/kg would not be to induce increase of its micronuclei.It was proved that Jiuxin Fumai Injection had no any mutagenicity in this experiment.