细胞凋亡信号传导通路的研究进展

细胞凋亡（apoptosis），是生物体细胞的主动消亡过程，是多细胞有机体调控机体发育、控制细胞衰老、维持内环境稳定的重要机制。细胞凋亡发生过程的启动和进行受到精确调控，具有独特而复杂的信号系统。各种凋亡信号通过信号传导通路传至细胞内，激活靶分子而产生细胞效应，引发细胞凋亡。一般认为，细胞凋亡存在三条主要通路：线粒体通路、内质网通路和死亡受体通路，各通路间互相联系，共同调节细胞凋亡。

The Progress on the Signal Transduction Pathways of Apoptosis

Apoptosis is a form of intrinsic cellular suicide program,which is a wide physiological process in multicellular organisms and critical for the development,the cell senescence and the tissue homeostasis.The initial and progress of apoptosis is precisely regulated.This review will summarize current knowledge of the signal transduction pathways of apoptosis.Broadly speaking,there are three pathways in apoptosis: death receptor pathway,mitochondrion pathway and endoplasmic reticulum pathway.These ways can cross-talk and regulate apoptosis coordinately.