实验恒河猴肺自发病变的组织学观察

目的 了解人工饲养条件下恒河猴脏器自发病变的发生情况，建立恒河猴自发病变的病理图谱。方法 采用常规组织学技术结合特殊染色方法，观察了各个年龄阶段的52只恒河猴肺的组织病理变化。结果 发现84．6％的肺存在不同程度的病变，包括各型肺炎、炎性细胞浸润、坏死、脓肿、结缔组织增生、纤维化等共17种病变。随年龄增长肺病变程度和病变发生率增加。结论 肺脏是恒河猴自发病变较严重的器官之一，自发病变对动物实验的干扰应引起足够重视。

Histopathology Observation of Lung Spontaneous Lesion in Macaca mulatta

Objective To study the histopathological changes in lungs spontaneous lesions of breeding %macaca mulatta.% Methods Lung samples from 2-20 years monkeys were investigated by routine histological technique.Results Various spontaneous lesions,totaling 17 kinds in different degrees,were found in 84.6% monkeys of the study,including pneumonia,inflammatory cell infiltration,degenerations,abscess,proliferation of fibrous tissue, and fibrosis.The degree and the freqency of lesions increased with age.Conclusion The spontaneous lesions of lung were often observed in %macaca mulatta% and its interference effect should be seriously taken.