| 犬尿氨酸通路在神经退行性疾病中的研究进展 |
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| 引用本文： | 常琪.犬尿氨酸通路在神经退行性疾病中的研究进展[J].中国比较医学杂志,2015,25(11):69-75. |
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| 作者姓名： | 常琪 |
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| 作者单位： | 中国医学科学院北京协和医学院药用植物研究所, 北京 100193;中国医学科学院北京协和医学院药用植物研究所, 北京 100193;中国医学科学院北京协和医学院药用植物研究所, 北京 100193;中国医学科学院北京协和医学院药用植物研究所, 北京 100193;中国医学科学院北京协和医学院药用植物研究所, 北京 100193;中国医学科学院北京协和医学院药用植物研究所, 北京 100193 |
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| 基金项目： | 科技部对欧盟科技合作专项(1108);新疆科技厅资助项目(20146021和201491174)。 |
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| 摘 要： | 犬尿氨酸通路是色氨酸代谢的主要途径,与亨廷顿病、阿尔茨海默病、帕金森氏症等神经退行性疾病的发生、发展有着密切联系。本文主要综述了犬尿氨酸通路代谢产物的神经生物学活性及其与相关神经退行性疾病的关系,为研究和治疗神经退行性疾病提供新的思路和方法。
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| 关 键 词： | 犬尿氨酸通路 神经退行性疾病 神经生物学活性 |
| 收稿时间： | 2015/9/21 0:00:00 |
| 修稿时间： | 2015/10/21 0:00:00 |
Research progress in the kynurenine pathway related with neurodegenerative diseases |
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| Chang Qi.Research progress in the kynurenine pathway related with neurodegenerative diseases[J].Chinese Journal of Comparative Medicine,2015,25(11):69-75. |
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| Authors: | Chang Qi |
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| Institution: | Institute of Medicinal Plant Development, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100193, China;Institute of Medicinal Plant Development, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100193, China;Institute of Medicinal Plant Development, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100193, China;Institute of Medicinal Plant Development, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100193, China;Institute of Medicinal Plant Development, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100193, China;Institute of Medicinal Plant Development, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100193, China |
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| Abstract: | The kynurenine pathway, a major route of tryptophan metabolism, is involved in the occurrence and development of some neurodegenerative diseases, such as Huntington's disease, Alzhermier's disease and Parkinson's disease. This article is focused on the literature review on the neurobiological properties of kynurenine pathway metabolites and their crucial role in related neurodegenerative diseases, for providing novel therapeutic interventions to neurodegenerative diseases. |
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| Keywords: | Kynurenine pathway Neurodegenerative diseases Neurobiological properties |
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