ADHD实验动物模型比较研究

目的总结ADHD动物模型的研究情况,分析各种模型的优势与不足,为建立理想ADHD动物模型提供参考,为今后ADHD的实验研究提供新思路。方法搜集ADHD动物模型相关文献,分析归纳各种模型的来源及应用范围,总结其优缺点。结果 ADHD模型主要分为四大类型:遗传学模型、神经损伤模型、人工筛选模型及环境适应性模型。四类模型建模目的不同,应用范围各异,互有优劣。结论按有关评价标准,尚无理想的ADHD动物模型,SHR大鼠是当前相对完善的模型。动物模型的选择应根据研究的目的进行筛选,建立理想的ADHD动物模型是重要的研究方向。

A comparative research for experimental animal model of ADHD

Objective To summarize the ADHD animal model and analysis the advantages and disadvantages of various models, providing reference to establish ideal animal model for ADHD and providing new way for the future study of ADHD. Methods Collecting ADHD animal models related literature, analyze the sources of the various models and application scope, summarizes the advantages and disadvantages. Results ADHD model mainly divided into four types: genetic model, the nerve injury model, artificial screening model and environmental adaptability. Four types of model modeling purpose is different, different application scope, advantages and disadvantages with each other. Conclusions According to the relevant evaluation standard, there is no ideal animal model of ADHD. SHR rats is the relatively perfect model. The animal model should be selected according to the purpose of the study screening, establishing the ideal ADHD animal model is the important direction of the current research. direction.