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新药长毒试验动物血液生化测定规范化研究系列之七--Beagle犬血液生化参考值的建立
引用本文:齐云,蔡润兰,刘彬,宋杨,王敏,李永超,赵德明.新药长毒试验动物血液生化测定规范化研究系列之七--Beagle犬血液生化参考值的建立[J].中国比较医学杂志,2006,16(4):201-203,207.
作者姓名:齐云  蔡润兰  刘彬  宋杨  王敏  李永超  赵德明
作者单位:1. 中国医学科学院,中国协和医科大学药用植物研究所,北京,100094
2. 中国农业大学实验动物研究所
基金项目:致谢:本文研究得到了北京通利试验动物养殖场程宗林、程宗贵同志的大力支持,在此谨致真诚谢意.
摘    要:目的 建立新药慢性毒性试验Beagle犬血液生化参考值。方法采用全自动生化测定仪对不同年龄、不同性别Beagle犬的血液生化值进行了测定。结果取得不同年龄、性别Beagle犬血液生化值平均值及参考值范围。部分生化指标受性别因素影响。ALP、CK有随年龄增长而降低的趋势。结论在新药慢性毒性试验中,参比参考值时应考虑到Beagle犬性别与年龄的因素。

关 键 词:Beagle  犬科  生物化学  血液  参考值  毒性试验  慢性
文章编号:1671-7856(2006)04-0201-04
收稿时间:2005-12-20
修稿时间:2005年12月20

Establishment of Normal Range and Values of Blood Biochemical Measurements in Beagle Dogs
QI Yun,CAI Run-lan,LIU Bin,SONG Yang,WANG Min,LI Yong-chao,ZHAO De-ming.Establishment of Normal Range and Values of Blood Biochemical Measurements in Beagle Dogs[J].Chinese Journal of Comparative Medicine,2006,16(4):201-203,207.
Authors:QI Yun  CAI Run-lan  LIU Bin  SONG Yang  WANG Min  LI Yong-chao  ZHAO De-ming
Abstract:Objective To establish normal values and ranges of blood biochemical measurements in Beagle dogs, to he used as reference values for long-term toxicity test. Methods Blood samples were taken from Beagle dogs in different age and sex. A number of blood biochemical parameters were measured with an automatic chemistry analyzer. Results Mean values and normal ranges of all data were obtained. Part of the biochemical values were influenced by sex difference. The activities of ALP and CK were weaker along with the increasing age of dogs. Conclusion In long-term toxicity test, it is necessary to pay attention to the influence of age and sex of Beagle dogs, when data obtained in an experiment are compared with their normal values and ranges.
Keywords:Beagle dogs  Biochemistry  blood  Reference data  Toxicity tests  chronic
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