| Abstract: | Objective: To observe the clinical effect of Rebixiao granule (RBXG) in treating repeatedly attacking acute gouty arthritis and through
experimental study on blood uric acid to explore RBXGs therapeutic mechanism.Methods: Ninety repeatedly attacking acute gouty arthritis patients were divided into the treated group (n = 60) and control group (n = 30). The treated group was treated with RBXG, and the control group was treated with Futalin tablets (diclofenac sodium).
The baseline treatment including good rest, low purine diet, sufficient water drinking and urine alkalization, etc. was then
given to both groups. Hypoxanthine 600 mg/kg and niacin 100 mg/kg was applied to hyperuricemic mice by gastrogavage to establish
the animal models.Results: The clinical effective rate of the treated group was 95.0% and that of the control 90.0%. Good therapeutic effects were
won, insignificant difference (P>0.05)was shown between the two groups. However, the cure rate of the treated group was 26.7% while that of the control group
was 10.0%, with significant difference (P<0.01) shown between them. The treated group had its blood uric acid lowered, which was significantly different (P<0.05) from that of the control group. The animal experiment indicated that all the three groups treated with different dosages
of RBXG, as well as the Ash bark and Smilax glabra rhizome groups had their blood uric acid content reduced in the hyperuricemic
mice.Conclusion: RBXG has a quicker initiation and better treatment effects than sole anti-inflammatory and analgesic agents on the treatment
of repeatedly attacking acute gouty arthritis, showing no obvious toxic or adverse reactions and therefore good for long-term
administration and likely to be a safe TCM preparation to control the symptoms and reduce the onsets of repeatedly attacking
of acute gouty arthritis. The animal experiment shows that both the compound preparation and part of the single ingredients
in the recipe have the function of reducing blood uric acid. However, the compound recipe has better therapeutic effects,
proving to be superior to single drugs.
Supported by Project of Science and Technology Commission Foundation of Jiangsu Province in 1998; |
