| Effect of Shashen Maidong Decoction(沙参麦冬汤) on Gastric Motility in vivo |
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| 引用本文： | 冯卫红,候家玉.Effect of Shashen Maidong Decoction(沙参麦冬汤) on Gastric Motility in vivo[J].Chinese Journal of Integrated Traditional and Western Medicine,1997(1). |
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| 作者姓名： | 冯卫红 候家玉 |
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| 作者单位： | Deportment of Pharmacology，Beijing University of TCM，Beijing 100029 |
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| 摘 要： | ＥｆｆｅｃｔｏｆＳｈａｓｈｅｎＭａｉｄｏｎｇＤｅｃｏｃｔｉｏｎｏｎＧａｓｔｒｉｃＭｏｔｉｌｉｔｙｉｎｖｉｖｏ￥ＦＥＮＧＷｅｉ－ｈｏｎｇａｎｄＨＯＵＪｉａ－ｙｕ（ＤｅｐｏｒｔｍｅｎｔｏｆＰｈａｒｍａｃｏｌｏｇｙ，ＢｅｉｊｉｎｇＵｎｉｖｅｒｓｉｔｙｏｆＴ...
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Effect of Shashen Maidong Decoction on Gastric Motility in vivo |
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| Authors: | FENG Wei-hong and HOU Jia-yu |
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| Abstract: | Objective: To evaluate the effect of Shashen Maidong Decoction (SSMDD) on gastric motility.Method: Effect of SSMDD on the gastric motility of mice and rats was observed in vivo by administration of SSMDD in various dosages and observation on gastric phenol red excretion rate, gastric emptying rate, frequency and amplitude of contraction of fundic longitudinal muscles, etc. Results: SSMDD could reduce markedly the gastric phenol red excretion rate of mice, antagonize the acceleration of gastric emptying induced by neostigmine, inhibit the frequency and amplitude of contraction of fundic longitudinal muscle, slow down the frequency and decrease the amplitude of gastric peristalsis, and reduce the gastric hypermotility induced by indomethacin significantly. Conclusion: SSMDD has evident inhibition action on motility of experimental animals in vivo, its mechanism might be related with adrenergic nerve and metabolism of prostaglandin E. |
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| Keywords: | Shashen Maidong Decoction gastric emptying ingastric pressure fundic longitudinal muscle antral circular muscle indomethacin reserpine |
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