| Effects of Chinese Kidney-Tonifying Herbal Medicine on M-Cholinergic Receptor and Acetylcholinesterase Activity in Dementia Mimetic Mice |
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| 作者姓名： | Qi-Zhong Mo Jun M Bin Gong Lian Ning Bao-Mei Wang |
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| 作者单位： | MO Qi-zhong，MA Jun，GONG Bin，NING Lian and WANG Bao-mei (Nuclear Medicine Laboratory of Shanghai University of Traditional Chinese Medicine，Shanghai (200032)) |
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| 摘 要： | Ｅｆｆｅｃｔｓ ｏｆ Ｃｈｉｎｅｓｅ Ｋｉｄｎｅｙ－Ｔｏｎｉｆｙｉｎｇ Ｈｅｒｂａｌ Ｍｅｄｉｃｉｎｅ ｏｎ Ｍ－Ｃｈｏｌｉｎｅｒｇｉｃ Ｒｅｃｅｐｔｏｒ ａｎｄ Ａｃｅｔｙｌｃｈｏｌｉｎｅｓｔｅｒａｓｅ Ａｃｔｉｖｉｔｙ ｉｎ Ｄｅｍｅｎｔｉａ Ｍ...
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Effects of Chinese Kidney-Tonifying herbal medicine on M-cholinergic receptor and acetylcholinesterase activity in dementia mimetic mice |
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| Authors: | Qi-Zhong Mo Jun M Bin Gong Lian Ning and Bao-Mei Wang |
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| Institution: | 1. Nuclear Medicine Laboratory of Shanghai University of Traditional Chinese Medicine, 200032, Shanghai
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| Abstract: | Objective: In order to study the effects of Chinese Kidney-tonifying (KT) herbal medicine on the M-cholinergic receptor(M-R) and the acetylcholinesterase (AchE ) activity in the models' cerebral cortex. Methods: Dementia mimetic mice models were formed with aluminum chloride. Results: The Muscarine receptor total receptor concentration (M-Rt) lowered and the AchE increased in the model significantly comparedwith healthy young mice. KT could markedly reduce the increase of AchE and elevate the lowered M-Rt in cerebral cortex of the dementia mimetic mice and improve the memory. Conclusions: KT is effective in preventingthe degeneration of cerebral function and presenile dementia. |
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| Keywords: | Kidney-tonifying dementia mimetic acetylcholinesterase M-cholinergic receptor |
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