| The Effect of Xuefu Zhuyu Decoction(血府逐瘀汤) on in vitro Endothelial Progenitor Cell Tube Formation |
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| 引用本文： | 高冬,吴立娅,焦雨欢,陈文元,陈岩,Ted J. Kaptchuk,逯波,宋军,陈可冀.The Effect of Xuefu Zhuyu Decoction(血府逐瘀汤) on in vitro Endothelial Progenitor Cell Tube Formation[J].Chinese Journal of Integrated Traditional and Western Medicine,2010,16(1):50-53. |
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| 作者姓名： | 高冬 吴立娅 焦雨欢 陈文元 陈岩 Ted J. Kaptchuk 逯波 宋军 陈可冀 |
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| 作者单位： | Department of Integrative Medicine;Fujian University of Traditional Chinese Medicine;Experimental Research Center;China Academy of Chinese Medical Sciences;Harvard Medical School;Xiyuan Hospital; |
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| 基金项目： | Supported by the National Natural Science Foundation of China (No.30772877); Basic Research Fund of China Academy of Chinese Medical Sciences(No.ZZ2006039); Fujian Academy of Integrative Medicine Foundation(No.3000-905010805) |
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| 摘 要： | <正>Objective:To observe the effect of Xuefu Zhuyu Decoction(血府逐瘀汤)-containing serum (XFZYD-CS) on endothelial progenitor cell(EPC) tube formation in vitro.Methods:Mononuclear cells from rat bone marrow were prepared in a Ficoll density gradient centrifuge.EPCs were separated by the differential attachment method,and observed with inverted microscope for the effect of XFZYD-CS on EPC tube formation. Results:After one day,EPCs exposed to the serum containing 5%,10%and 15%XFZYD-CS formed typical tubes or vessel networks.The tube formation time was two days ahead of the control group and the size of most tubes in the serum groups was smaller than in the control group.Conclusion:XFZYD-CS could induce EPC angiogenesis and hasten tube formation,especially in capillary vessels.The study provides experimental evidence for the plausibility of Xuefu Zhuyu Decoction in the treatment of ischemic diseases.
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| 关 键 词： | 血府逐瘀汤 内皮祖细胞 外管 骨髓单个核细胞 消失模铸造 密度梯度离心 疾病治疗 分离方法 |
| 收稿时间： | 10 October 2010 |
The effect of Xuefu Zhuyu Decoction (血府逐瘀汤) on in vitro endothelial progenitor cell tube formation |
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| Authors: | Dong Gao Li-ya Wu Yu-huan Jiao Wen-yuan Chen Yan Chen Ted J Kaptchuk Bo Lu Jun Song and Ke-ji Chen |
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| Institution: | GAO Dong,WU Li-ya,JIAO Yu-huan,CHEN Wen-yuan CHEN Yan,Ted J.Kaptchuk,LU Bo,SONG Jun,, CHEN Ke-ji 1.Department of Integrative Medicine,Fujian University of Traditional Chinese Medicine,Fuzhou(350108),China,2. Experimental Research Center,China Academy of Chinese Medical Sciences,Beijing(100700),3.Harvard Medical School,Boston,MA02215,USA,4.Xiyuan Hospital,Beijing(100091) |
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| Abstract: | Objective To observe the effect of Xuefu Zhuyu Decoction (血府逐瘀汤)-containing serum (XFZYD-CS) on endothelial progenitor cell (EPC) tube
formation in vitro. |
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| Keywords: | Xuefu Zhuyu Decoction endothelial progenitor cells tube formation |
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