| Buyang Huanwu Decoction (补阳还五汤) Reduces Infarct Volume and Enhances Estradiol and Estradiol Receptor Concentration in Ovariectomized Rats after Middle Cerebral Artery Occlusion |
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| 作者姓名： | LIU Bai-yan SONG Xiao-ling YI Jian CAI Guang-xian |
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| 作者单位： | Key Laboratory of Internal Medicine, Hunan University of Traditional Chinese Medicine, Changsha (410007), China |
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| 基金项目： | Supported by National Natural Science Foundation of China(No.30300470,30472217,30873355,and 81273989);Ministry Education of China(No.209087);Foundation of Educational Commission of Hunan Province(No.08A049) |
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| 摘 要： | Objective：To investigate the effect of Buyang Huanwu Decoction（补阳还五汤,BYHWD） on estradiol（E2） and estradiol receptor（ER） in serum and brain in ovariectomized rats after middle cerebral artery occlusion（MCAO）.Methods：Adult female rats were ovariectomized and focal cerebral ischemic was induced by MCAO.Rats were randomly divided into normal,ovariectomy（OVX）,MCAO,OVX＋MCAO,OVX＋MCAO＋E2,and OVX＋MCAO＋BYHWD group.Rats were administered BYHWD 5 g/kg daily,estradiol valerate 500 μg/kg per day or distilled water for 7 consecutive days.Neuronal function and infarct volume were measured on day 7 after artery occlusion,and E2 and ER concentration in serum and brain were checked by enzyme-linked immunosorbent assay.Results：BYHWD significantly improved the neurological behavior,reduced the infarction volume,increased E2concentration in serum and brain,and increased ER concentration in the brain in ovariectomized rats after MCAO.Conclusion：The neuroprotective effects of BYHWD are associated with estrogen and its receptor.
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| 关 键 词： | 补阳还五汤 去卵巢大鼠 雌激素受体 雌二醇 死体积 大脑 动脉 闭塞 |
Buyang Huanwu Decoction (补阳还五汤) reduces infarct volume and enhances estradiol and estradiol receptor concentration in ovariectomized rats after middle cerebral artery occlusion |
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| Authors: | LIU Bai-yan SONG Xiao-ling YI Jian and CAI Guang-xian |
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| Institution: | 1. Key Laboratory of Internal Medicine, Hunan University of Traditional Chinese Medicine, Changsha, 410007, China
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| Abstract: | Objective To investigate the effect of Buyang Huanwu Decoction (补阳还五汤, BYHWD) on estradiol (E2) and estradiol receptor (ER) in serum and brain in ovariectomized rats after middle cerebral artery occlusion (MCAO). Methods Adult female rats were ovariectomized and focal cerebral ischemic was induced by MCAO. Rats were randomly divided into normal, ovariectomy (OVX), MCAO, OVX+MCAO, OVX+MCAO+E2, and OVX+MCAO+BYHWD group. Rats were administered BYHWD 5 g/kg daily, estradiol valerate 500 μg/kg per day or distilled water for 7 consecutive days. Neuronal function and infarct volume were measured on day 7 after artery occlusion, and E2 and ER concentration in serum and brain were checked by enzyme-linked immunosorbent assay. Results BYHWD significantly improved the neurological behavior, reduced the infarction volume, increased E2 concentration in serum and brain, and increased ER concentration in the brain in ovariectomized rats after MCAO. Conclusion The neuroprotective effects of BYHWD are associated with estrogen and its receptor. |
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| Keywords: | Buyang Huanwu Decoction focal cerebral ischemic estrogen estrogen receptor Chinese medicine |
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