希罗达联合草酸铂治疗晚期胃癌的临床观察

目的:观察草酸铂联合希罗达治疗晚期胃癌的疗效及安全性。方法:73例晚期胃癌患者随机分为两组,治疗组采用草酸铂85 mg/?静脉滴注2 h,第1天,希罗达1000 mg/?口服,第1~14天,每3周为一周期,对照组草酸铂85 mg/m2静脉滴注3 h,第1天,CF200 mg/m2静脉滴注2 h,第1~5天,5-Fu 300 mg/m2静脉点滴5 h,第1~5天,每3周为一个周期。每例患者至少接受4个疗程,按照WHO实体瘤近期客观疗效评定标准进行评价。结果:治疗组(希罗达组)有效率50%,对照组有效率46.8%,无统计学意义(P>0.05)两组疗效相当。两组重度毒性反应,治疗组(希罗达组)少于对照组差异有统计学意义(P<0.05),其中重度白细胞减少,两组对比差异无统计学意义,而重度腹泻,便秘,重度口腔炎及重度恶心、呕吐,两组对比有统计学意义(P<0.05)。外周神经毒性为L-OHP的突出毒副反应,呈可逆性。结论:L-OHP联合希罗达治疗晚期胃癌疗效肯定,毒副反应轻。有利于提高化疗患者的生存质量,患者乐于接受治疗,依从性好。

Therapy of Xeloda combined with oxaliplatin in advanced gastric cancer

Objective: To evaluate the efficacy and safety of Xeloda combined with oxaliplatin in the treatment of patients with advanced gastric cancer.Methods: 56 patients with advanced gastric cancer were randomly divided into two groups.The treatment group were administrated with oxaliplatin plus Xeloda(oxaliplatin 85 mg/m2 infused intravenously for 3h day 1;Xeloda taken orally 1000 mg/m2 day 1 to 14,repeated 21 days).The control group were administrated with oxaliplatin、CF and 5-Fu(oxaliplatin 85 mg/m2 infused intravenously for 3 h day 1,CF200 mg/m2 and 5-Fu 300 mg/m2 infused intravenously day 1 to 5,repeated 21 days).Each patient should complete at least four cycles and was evaluated according to WHO solid tumor efficacy of the recent assessment criteria.Results: The effective rate were 50% and 46.8% in the treatment group and control group respectively.But no statistical significance were dectected(P>0.05).The side effects of severe toxicity in treatment group(Xeloda group) were less than that of the control group significantly(P<0.05).But there is no significant difference between the two groups in severe leukopenia.While the moderate and severe diarrhea,constipation,severe stomatitis and severe nausea,vomiting in the two groups was statistically significant(P<0.05).Peripheral nerve toxicity of LOHP prominent toxicity was reversible.Conclusion: L-OHP combined Xeloda in the treatment of advanced gastric cancer is effective and has mild side effects.It helps the patients improve their quality of life;they are willing to accept the treatment.