血小板激活因子拮抗剂BN52021对缺血再灌注损伤的大鼠肝脏的保护作用 |
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引用本文: | 张中乐. 血小板激活因子拮抗剂BN52021对缺血再灌注损伤的大鼠肝脏的保护作用[J]. 河南医学研究, 1998, 7(1): 10-13 |
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作者姓名: | 张中乐 |
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作者单位: | 洛阳医学高等专科学校病理生理学教研室,洛阳医学高等专科学校附属医院普外,洛阳医学高等专科学校病理教研室 |
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摘 要: | 目的:研究血小板激活因子拮抗剂BN52021对大鼠缺血再灌注肝脏的影响。方法:将大鼠分为三组,对照组未进行缺血及药物治疗;缺血再灌注组行40min缺血,然后行120min再灌注;血小板激活因子拮抗剂治疗组行40min缺血,120min再灌注,再灌注时给予BN52021(10mg/kg),比较各组血清SGPT、SGOT、AKP及γ-GT,肝脏的细胞能荷。结果:用血小板激活因子拮抗剂治疗组血清SGPT、SGOT、AKP、γ GT均较缺血再灌注组显著降低,能荷水平明显升高。结论:血小板激活因子拮抗剂BN52021用于大鼠肝脏缺血再灌注可减少肝脏的损害,提示血小板激活因子(PAF)对肝脏缺血再灌注损伤的发生起一定的作用,血小板激活因子拮抗剂BN52021有可能用于肝脏缺血再灌注损伤的治疗。
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关 键 词: | 肝脏;缺血再灌注;血小板激活因子;BN52021 |
Protection of BN 52021 on Liver Ischemia Reperfusion Injuries in Rats |
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Abstract: | Objective: Platelet activating factor antagonist BN 52021 on ischemia-reperfusion(I/R)injury of rat liver was studied.Methods: Rats were divided into 3 groups.The normal control group was not subjected to hepatic ischemia and no treatment was given.The I/R injury group was subjected to 40 minutes of ischemia followed by reperfusion for 120 minutes.The Anti PAF treatment group was subjected of reperfusion and BN 52021 10 mg/kg was administered at reperfusion SGPT,SGOT,AKP and γ GT and hepatic energy charge were compared.Results: The anti PAF treatment group serum levels of SGPT,SGOT,AKP and γ GT were significantly lower than I/R injury group. Energy charge level was significantly higher with anti PAF treatment (P<0.05).Conclusion: Anti PAF BN 52021 treatment at reperfusion decreased damage of rat liver subjected to I/R injury.Anti PAF BN 52021 may be useful in the treatment of hepatic I/R injury. |
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Keywords: | liver ischemia reperfusion PAF BN 52021 |
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