安徽省皖南地区261例肾组织活检临床病理资料分析

目的:了解肾小球疾病临床与病理之间的关系,认识肾活检在肾脏病诊治中的价值。方法:回顾性分析261例肾活检的临床及病理资料。结果:①原发性肾小球疾病190例(占72.8%),继发性肾小球疾病71例(占28.2%)。原发性肾小球疾病以IgA肾病为主(占48.9%)。继发性肾小球疾病以狼疮性肾炎为主(占83.1%)。②临床类型占前2位的依次为慢性肾炎(62.1%)和肾病综合征(23.4%)。慢性肾炎最常见的病理类型依次是IgA肾病(51.9%)、狼疮肾炎(21.6%)和系膜增生性肾炎(9.9%);肾病综合征最常见的病理类型依次是膜性肾病(36.1%)、微小病变性(21.3%)和狼疮肾炎(19.7%)。结论:原发性肾小球疾病是目前最主要的肾小球疾病;慢性肾炎是最常见的临床类型,其病理类型主要是IgA肾病和狼疮性肾炎。肾活检对肾脏病的明确诊断、指导治疗及判断预后均有非常重要的作用。

Clinicopathological analysis of 261 cases of renal biopsy in Wannan area of Anhui province

Objective： To investigate the relationship between clinic and pathology in glomerular disease, and realize the value of renal biopsy in diagnosis and treatment of kidney disease. Meth- ods ： The clinical and pathological data of 261 cases of renal biopsy were retrospectively analyzed. Results ： ①There were 190 cases （72.8%） of primary glomerular disease and 71 cases （28.2%） of secondary glomerular disease. Primary glomerular disease mainly was IgA nephropathy （48.9%）. Secondary glomerular disease was dominated by lupus nephritis （83.1%）. ②The first two clinical types were chronic nephritis （62.1%） and nephrotic syndrome （23.4%）. The most common pathological types of chronic nephritis were IgA nephropathy （51.9%） , lupus nephritis （21.6%） and MsPGN （9.9%）. Membranous nephropathy （36.1%） , minimal change disease （21.3%） and lupus nephritis （ 19.7% ） were the most common types of nephrotic syndrome. Conclusion： Primary glomerular disease was the most common renal glomerular disease; Chronic nephritis was most common clinical manifestation, of which the pathological types were IgA ne- phropathy and lupus nephritis. Renal biopsy was useful for the diagnosis, guiding treatment and judging prognosis of kidney disease.