| Bcl-2 对病理性瘢痕成纤维细胞增殖活性及细胞凋亡的影响 |
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| 引用本文： | 唐世杰,胡素銮,王玉银.Bcl-2 对病理性瘢痕成纤维细胞增殖活性及细胞凋亡的影响[J].汕头大学医学院学报,2002,15(4):211-211,221,F002. |
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| 作者姓名： | 唐世杰 胡素銮 王玉银 |
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| 作者单位： | 1. 汕头大学医学院第二附属医院烧伤整形外科,广东,汕头,515041
2. 中南大学湘雅二医院烧伤整形外科,湖南,长沙,410011 |
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| 基金项目： | 广东省高教厅自然科学重点项目资助 (9812 ) |
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| 摘 要： | 目的：研究Bcl-2对病理性瘢痕成纤维细胞的生物学作用。方法：用MTT法检测成纤维细胞增殖活性，流式细胞术检测细胞凋亡情况。结果：Bcl-2能抑制成纤维细胞的凋亡，促进其增殖。结论：Bcl-2在病理性瘢痕的形成中起一定的作用。
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| 关 键 词： | 瘢痕 成纤维细胞 Bcl－2 凋亡 |
| 文章编号： | 1007-4716(2002)04-0211-02 |
An Experimental Study of Bcl-2 on Proliferatin and Apoptosis of Fibroblast Derived from Pathological Scars in vitro |
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| Tang Shijie,Hu Suluan.An Experimental Study of Bcl-2 on Proliferatin and Apoptosis of Fibroblast Derived from Pathological Scars in vitro[J].Journal of Shantou University Medical College,2002,15(4):211-211,221,F002. |
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| Authors: | Tang Shijie Hu Suluan |
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| Abstract: | Objective: To investigate the biological effects of Bcl-2 on fibroblast derived from pathological scars.Me-hods: The MTT method and the FCM were used to test fibroblast proliferation activity and cell apoptosis rate.Results: Bcl-2 protein could accelerate the proliferation of fibroblast in vitro .It could inbibit the apoptosis rate of fibrablast in vitro.Conclusion:Bcl-2 may play a role in the pathogenesis of keloid and hypertrophic scarring |
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| Keywords: | Scar Fibroblast Bcl-2 Apoptosis |
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