| 藏药八味沉香散对H_2O_2所致乳鼠心肌细胞氧化应激损伤的保护作用 |
| |
| 引用本文： | 朱艳媚,芦殿香,曾阳,陈志,陈梅花.藏药八味沉香散对H_2O_2所致乳鼠心肌细胞氧化应激损伤的保护作用[J].青海医学院学报,2011,32(2):109-112. |
| |
| 作者姓名： | 朱艳媚 芦殿香 曾阳 陈志 陈梅花 |
| |
| 作者单位： | 1. 青海大学医学院
2. 青海师范大学生命地理学院 |
| |
| 基金项目： | 国家自然基金(81060368); 西部之光项目-中国科学院科发人教字2009(236) |
| |
| 摘 要： | 目的探讨八味沉香散对过氧化氢（H2O2）所致乳鼠心肌细胞氧化应激损伤的保护作用。方法 SD乳鼠心肌细胞原代培养,H2O2诱导心肌细胞氧化应激损伤,用不同剂量藏药八味沉香散处理24 h后,测定培养液中乳酸脱氢酶（LDH）、肌酸激酶（CK）、过氧化氢酶（CAT）的含量;同时检测培养液中超氧化物歧化酶（SOD）、丙二醛（MDA）及谷胱甘肽过氧化物酶（GSH-Px）的活性。结果八味沉香散可明显减轻H2O2所致乳鼠心肌细胞培养液中LDH、CK和CAT的释放量,同时能够升高SOD、GSH-Px活性,降低MDA活性。结论八味沉香散对H2O2所致乳鼠心肌细胞氧化应激损伤有明显保护作用。
|
| 关 键 词： | 八味沉香散 H2O2 心肌细胞 氧化应激 |
TIBETAN BAWEI CHENXIANG POWDER ON H_2O_2 INDUCED OXIDATIVE STRESS IN NEONATAL RAT CARDIOMYOCYTES PROTECTIVE EFFECT |
| |
| Zhu Yanmei,Lu Dianxiang,Zeng Yang,Chen Zhi,Chen Meihua.TIBETAN BAWEI CHENXIANG POWDER ON H_2O_2 INDUCED OXIDATIVE STRESS IN NEONATAL RAT CARDIOMYOCYTES PROTECTIVE EFFECT[J].Journal of Qinghai Medical College,2011,32(2):109-112. |
| |
| Authors: | Zhu Yanmei Lu Dianxiang Zeng Yang Chen Zhi Chen Meihua |
| |
| Institution: | Zhu Yanmei1,Lu Dianxiang1,Zeng Yang2,Chen Zhi2,Chen Meihua2 (1.Qinghai University School of Medicine,2.Qinghai Normal University habitat College) |
| |
| Abstract: | Objective To study the protective effect of Tibetan Bawei Chenxiang Powder on oxidative stress injury in cardiomyocytes of neonatal rats induced by H2O2. Methods H2O2 was used to induce oxidative stress injury in primary cultured cardiomyocytes of neonatal rats.The content of lactate dehydrogenase(LDH),muscle Kinase(CK),catalase(CAT) and the activity of superoxide dismutase(SOD),malondialdehyde(MDA),glutathione peroxidase(GSH-Px) in culture medium were detected after treated by Tibetan Bawei Chenxiang Powde... |
| |
| Keywords: | Tibetan Bawei Chenxiang Powder H2O2 Cardiomyocytes Oxidative stress |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
