| 川芎嗪对大鼠癫痫放电神经元超微结构的影响 |
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| 引用本文： | 雷水生,张端莲,朱晓琴,胡祁生,余瑛,熊燕娥,李红,陕光. 川芎嗪对大鼠癫痫放电神经元超微结构的影响[J]. 河南中医学院学报, 2003, 18(2): 23-25 |
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| 作者姓名： | 雷水生 张端莲 朱晓琴 胡祁生 余瑛 熊燕娥 李红 陕光 |
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| 作者单位： | [1]湖北省成宁医学院皮肤科教研室，湖北省咸宁市437100 [2]武汉大学医学院组织胚胎学教研室 [3]武汉大学医学院生理学教研室 [4]武汉大学医学院 |
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| 基金项目： | 湖北省自然科学基金资助课题 (批准号 :2 0 0 0J0 78) |
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| 摘 要： | 目的：研究川芎嗪(TMP)对大鼠癫痫放电时其大脑神经元超微结构的变化。方法：通过青霉素致癫大鼠模型，采用BL-410生物机能实验系统记录腹腔注射不同剂量川芎嗪对双侧大脑皮层癫痫放电，观察川芎嗪对癫痫放电频率的影响，并用透射电镜观察大脑皮层神经元超微结构的变化。结果：川芎嗪可使大鼠癫痫放电频率减慢，并且随着频率的减慢，大脑皮层神经元超微结构形态也恢复正常。结论：川芎嗪能明显押制大鼠癫痫放电，并使神经元内的细胞器结构恢复正常。
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| 关 键 词： | 川芎嗪 大鼠 癫痫 放电 神经元 超微结构 |
| 文章编号： | 1006-3234(2003)02-0023-03 |
| 修稿时间： | 2002-12-18 |
The Effect of Lingustrazine on Changes of Neuronal Ultrastructure in Rat''''s Epileptic Discharge |
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| Lei Shuisheng,Zhang Duanliang,Zhu Xiaoqin,Hu Qisheng,Yu Ying,Xiong Yane,Li Hong,Shan Guang. The Effect of Lingustrazine on Changes of Neuronal Ultrastructure in Rat''''s Epileptic Discharge[J]. Journal of Henan University of Chinese Medicine, 2003, 18(2): 23-25 |
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| Authors: | Lei Shuisheng Zhang Duanliang Zhu Xiaoqin Hu Qisheng Yu Ying Xiong Yane Li Hong Shan Guang |
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| Abstract: | Objective: To study the effects of lingustrazine on changes of neuronal ultrastructure in rat's epileptic discharge. Methods: The animal modles of rat cerebrum cortex on discharge of neuronal ultrastructure were made by penicillin. Use BL-410 data acquisition and analysis system to record discharge of neuronal ultrastructure of cerebrum cortex and observe the effects of TMP on amplitude and frequency of discharge of neuronal ultrastructure. Use transmission electron microscope to observe the changes of neuronal ultrastructure of cerebrum cortex. Results: Lingustrazine can slow down the frequency of discharge. With the reducing frequency, neuronal ultrastructure will return back to normal. Conclusion: Lingustrazine could significantly inhibit rat's epileptic discharge. |
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| Keywords: | epilepsy rats lingustrazine neuron ultrastructure |
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