脑钠肽及高敏C反应蛋白检测与慢性心力衰竭的关系

目的 探讨脑钠肽（BNP）与高敏C反应蛋白（hs-CRP）在辛伐他汀治疗慢性心力衰竭前后检测值的变化,了解二者的关系.方法 将门诊及住院患者共85例分为左室收缩功能衰竭常规治疗组40例、辛伐他汀治疗组45例,同时设心功能正常对照组35例.辛伐他汀组在常规治疗基础上再加用辛伐他汀20 mg/d治疗,治疗前及治疗后12周均测BNP、hs-CRP.结果 BNP和hs-CRP与心力衰竭严重程度相关,治疗12周后,2组BNP活性均下降（P〈0.05）,且以他汀组变化更明显,与对照组比较差异有统计学意义（P〈0.05）.结论 慢性心力衰竭患者在接受常规治疗的同时,加用辛伐他汀治疗可明显降低BNP和hs-CRP的含量;hs-CRP及BNP联合检测可作为慢性心力衰竭诊断、病情评估及疗效监测的重要临床指标.

Brain natriuretic peptide and high sensitivity C-reactive protein in patients with heart failure

Objective Investigate brain natriuretic peptide(BNP) and high sensitivity C-reactive protein changes in patients with chronic heart failure(CHF)treated by simvastatin,understanding the relationship between them.Methods A total of 85 cases of outpatient and inpatient,were divided into left ventricular failure in 40 patients with conventional therapy,and simvastatin treatment of 45 patients,heart function was normal control group of 35 cases.With simvastatin plus statin group(20 mg /d)treatment,treatment for 12 weeks before and after treatment were measured BNP and high sensitivity C-reactive protein.Results BNP and high-sensitivity C-reactive protein and severity of heart failure,treatment after 12 weeks,two groups of BNP activity decreased(P<0.05),and the more obvious changes in the statin group,compared with the control group the difference was statistically significant(P<0.05).Conclusion Chronic heart failure patients receiving conventional therapy,combing with simvastatin,can significantly reduce the BNP and high-sensitivity C-reactive protein levels.