168例慢性HBV感染者HBV基因型分布调查分析

目的探讨HBV基因型与乙肝的临床转归关系。方法应用PCR微板核酸分子杂交ELISA法检测168例慢性HBV感染者的HBV基因型，了解在各临床类型中HBV基因型的分布情况，阐明HBV基因型与HBeAg的关系；HBV基因型与乙肝临床转归的关系；HBV基因型与年龄性别的关系。结果168例慢性HBV感染者中B基因型有78例占46．43％，C基因型有90例占53．57％。在肝硬化与肝癌病人中C基因型（73．17％）明显多于B基因型（26．83％），统计学分析有明显差异（P〈0．05）。90例C基因型病人HBeAN阳性62例，HBeAg阴性28例，两者比较有显著性差别（P〈0．05）。在高年龄组病人中以C基因型为主。结论HBV基因型与乙肝临床转归有密切关系，C基因型是导致HBeAg持续阳性，引起肝硬化、肝癌的主要因素之一。

Survey of HBV genotype distribution in 168 cases of chronic HBV infection

Objective To discuss the relationship between HBV genotypes and the clinical outcome of hepatitis B. Methods HBV genotypes were detected by PCR-DNA hybridization-plate-ELISA in 168 cases of chronic HBV infection, to understand HBV genotype distribution of different clinical types, clarify the rclationship between HBeAg and HBV genotype the relationship between HBV genotype and Clinical outcome of the liver; the relationship between HBV genotype and age-sex. Results In 168 cases of chronic HBV infection,there were 78 cases of genotype B （46.43%）, 90 cases of C genotype （53.57%）. In patients with liver cirrhosis and liver cancer, C genotype （73.17%） was significantly more than genotype B （26.83%）, with statistically significantly difference （P〈0.05）. In 90 cases of C genotype, 62 patients were HBeAg positive and 28 cases HBeAg negative, and there was a significant difference （P 〈 0.05 ）. In the high age group C genotype was dominant. Conelusion HBV genotype and clinical outcome of hepatitis B have the close relation, C genotype is one of primary causes of sustained HBeAg positive, liver, cirrhosis, and liver cancer.