来氟米特和甲氨喋呤治疗活动性类风湿关节炎的对比观察

目的 研究来氟米特治疗活动期类风湿关节炎的临床疗效和安全性。方法 治疗组（来氟米特）和对照组（甲氨喋呤）各２４例分别使用来氟米特、甲氨喋呤治疗。参与疗效综合评估的指标有晨僵、关节疼痛水平、关节疼痛数、关节肿胀数、医生及病人的评估、血沉、Ｃ－反应蛋白、类风湿因子滴度。以总改善百分率对疗效进行综合评估。结果 治疗１２周，治疗和对照组病人面观察指标均有明显改善。总疗效来氟米特组为９１．６７％，甲氨喋呤为

The efficacy and safety of leflunomide in the treatment of active rheumatoid arthritis compared to methotrexate

Objective To study the efficacy and safety of leflunomide (LEF) in the treatment of active rheuma toid arthritis (RA) compared to methotrexate(MTX).Methods Fourty eight patients with active RA were treated with LEF 20mg/qd( n =24) or MTX 15mg/week ( n =24).Both groups were similar in demography and disease activity at baseline.Efficacy and safety of the treatment were evaluated according to various parameter changes.Results At week 12,assessment of joint scores,duration of morning stiffness,ESR,pain intensity levels,power of gripping levels,CRP and RF titers were significantly improved in the two groups.The total efficacy rate were 91.67% (LEF) and 70.84%(MTX) respectively.LEF and MTX were well tolerated.The drug related adverse events occurred in 20.83% in LEF group and 50.00% in MTX group.Conclusions LEF is an efficacious drug for RA and statistically equivalent to MTX,but it is probably safer than MTX.