| 丹参和钙通道拮抗剂抗LDL氧化作用的对比研究 |
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| 引用本文： | 吴卫平,金泽武.丹参和钙通道拮抗剂抗LDL氧化作用的对比研究[J].北京医学,1995,17(3):133-135. |
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| 作者姓名： | 吴卫平 金泽武 |
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| 作者单位： | 中国人民解放军总医院神经内科，日本弘前大学病院，解放军２６１医院 |
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| 摘 要： | 提取健康成人血浆中的低密度脂蛋白（ＬＤＬ），与丹参和硝苯吡啶、尼索地平及Ｃｕ＾＋透析，分别于透析后２４、４８及７２小时从各组ＬＤＬ中提取脂类进行薄层层析（ＴＬＣ）。结果表明，Ｘ带可作为脂质过氧化的一个重要指标，丹参具有拮抗ＬＤＬ氧化的作用，这可能是其防治心脑血管病的重要机理之一。
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| 关 键 词： | 氧化型 丹参 钙通道阻滞剂 低密度脂蛋白 |
The comparison between radix salviae miltiorrhizae(RSM )and nisoldipine nifedipine on the effect of antiperoxidation of low density lipoprotein |
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| Wu Weping,et al.The comparison between radix salviae miltiorrhizae(RSM )and nisoldipine nifedipine on the effect of antiperoxidation of low density lipoprotein[J].Beijing Medical Journal,1995,17(3):133-135. |
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| Authors: | Wu Weping |
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| Abstract: | The oxidized LDL generated by dialysing LDL from healthy persons with CuCl2 solution was used as a model to investigate the antioxidate property of RSM and nisoldipine nifeldipine(Ni). The results showed that the spot X was clearly found on the thin layer chromatography(TLC)after dialysis of LDL with CuCl2 solution or with nisoldipin nifedipine and CuCl2. However, the spot X was not found in RSM group.The analysis of lipid constituents in LDL by scanning showed that the percentage of spot X in RSM group was significantly lower than those in Cu group and Ni groups. The results indicated that the spot X may be an important indicator for lipoprotein peroxidizability and RSM plays a potential role in antioxidation of LDL Iipids. |
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| Keywords: | Oxidized LDL Radix salviae miltiorrhizae Calcium channel antagonists |
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