阿立哌唑与利培酮治疗精神分裂症的对照研究

目的比较阿立哌唑与利培酮对精神分裂症的疗效及安全性。方法将60例精神分裂症患者随机分为两组,阿立哌唑组30例,利培酮组30例,疗程8周。在治疗前及治疗2、4、6、8周末分别采用阳性与阴性症状量表（PANSS）评定疗效,以治疗中出现的症状量表（TESS）评定药物不良反应。结果两组治疗后PANSS评分均有显著下降,阿立哌唑组与利培酮组的显效率分别为76.7%和73.3%,疗效相当。阿立哌唑组锥体外系副作用、体重增加和月经周期改变较利培酮组少而轻,且对催乳素水平没有影响。结论阿立哌唑与利培酮对精神分裂症均有较好的疗效,但阿立哌唑的药物不良反应比利培酮少,且不影响催乳素水平,是一种有效、安全的抗精神病药物。

A controlled study of aripiprazole and risperidone in treatment of schizophrenia

Objective To compare the efficacy and safety of aripiprazole and risperidone in the treatment of schizophrenia.Methods 60 patients with schizophrenia were randomly divided into two groups： aripiprazole group（n=30） and risperidone group（n=30）.The therapeutic effects were evaluated by PANSS,and side effects were assessed by TESS before and after 2,4,6 and 8 treatment weeks.Results The rates of marked improvement in aripiprazole group and risperidone group were 76.7% and 73.3%,respectively.Conclusion Both aripiprazole and risperidone have good effective in the treatment of schizophrenia.But aripiprazole has less adverse effects.It＇s an effective and safe antipsychotic drug.