尿微量白蛋白免疫球蛋白G和α1微球蛋白在儿童过敏性紫癜早期肾损伤中的诊断价值

目的探讨尿微量白蛋白（MA）、免疫球蛋白G（IgG）和α1微球蛋白（α1-MG）检测在儿童过敏性紫癜（HSP）早期肾损伤中的诊断价值。方法采用散色比浊法检测45例HSP和49例过敏性紫癜性肾炎（HSPN）儿童尿MAI、gG和α1-MG的水平,通过与50例正常对照组儿童比较,评价其在HSP早期肾损伤中的诊断价值。结果 HSP和HSPN儿童中尿MAI、gG和α1-MG水平均显著高于正常对照组（P〈0.05）,尿MA在HSPN组中的水平显著高于HSP组（P〈0.05）,而尿IgG和α1-MG水平在HSP和HSPN组中并无显著差异（P〉0.05）。结论尿MAI、gG和α1-MG均可诊断儿童HSP早期肾损伤情况,且指标尿MA还可反映HSP肾损伤严重程度,对临床早期治疗有一定价值。

Diagnostic value of urine microalbumin,immunoglobulin G and α1-microglobulinon on early renal injuries of children with Henoch-Schonlein purpura

Objective To explore the clinical diagnostic value of urine microalbumin（MA）,immunoglobulin G（IgG） and α1-microglobulin（α1-MG） on early renal injuries of children with Henoch-Schonlein purpura（HSP）.Methods Urine MA,IgG and α1-MG were tested by rate nephelometry method in 45 cases with HSP and 49 cases with Henoch-Schonlein purpura Nephritis（HSPN）,which were compared with 50 normal control children.Results The levels of urine MA,IgG and α1-MG in HSP and HSPN were significantly higher than those in normal control group（P〈0.05）,and the levels of urine MA in HSPN were significantly higher than those in HSP（P〈0.05）.There was no significant difference in urine IgG and α1-MG between HSP and HSPN（P〉0.05）.Conclusion Urine MA,IgG and α1-MG can diagnose early renal injuries of children with HS.