| 慢性缺氧对大鼠岩神经节神经元ASIC1a和ASIC1b表达的影响 |
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| 引用本文： | 杨荫,郑煜,陈祁,王乾成,赵书,陈丽.慢性缺氧对大鼠岩神经节神经元ASIC1a和ASIC1b表达的影响[J].西部医学,2011,23(3):405-407. |
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| 作者姓名： | 杨荫 郑煜 陈祁 王乾成 赵书 陈丽 |
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| 作者单位： | 四川大学华西基础医学与法医学院生理学教研室,四川,成都,610041 |
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| 基金项目： | 国家自然科学基金(No.30370530) |
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| 摘 要： | 目的探讨慢性缺氧对大鼠岩神经节神经元酸敏感离子通道（acid-sensingion channels,ASICs）的两种亚型ASIC1a和ASIC1b表达的变化。方法建立大鼠慢性缺氧模型（6 h/d,12 d）,用常规免疫组化法（PV法）观察正常大鼠及慢性缺氧大鼠岩神经节神经元ASIC1a和ASIC1b的表达。结果正常大鼠岩神经节存在ASIC1a和ASIC1b阳性表达神经元;慢性缺氧组大鼠岩神经节ASIC1a和ASIC1b阳性神经元明显多于正常组（P〈0.05）。结论慢性缺氧能上调大鼠岩神经节神经元ASIC1a和ASIC1b的表达。
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| 关 键 词： | 岩神经节 酸敏感离子通道 慢性缺氧 |
Effect of chronic hypoxia on expression of acid-sensing ion channel 1a and 1b of neurons in petrosal ganglions of rats |
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| YANG Yin,ZHENG Yu,CHEN Qi,et al.Effect of chronic hypoxia on expression of acid-sensing ion channel 1a and 1b of neurons in petrosal ganglions of rats[J].Medical Journal of West China,2011,23(3):405-407. |
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| Authors: | YANG Yin ZHENG Yu CHEN Qi |
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| Institution: | YANG Yin,ZHENG Yu,CHEN Qi,et al(Department of Physiology,West China School of Preclinical and Forensic Medicine,Sichuan University,Chengdu 610041) |
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| Abstract: | Objective To investigate the effect of chronic hypoxia on expression of ASIC1a and ASIC1b of the neurons in petrosal ganglions of rats.Methods Sprage-Dawley rats were randomly divided into normal group and chronic hypoxia group.Chronic hypoxia models of rats were established(6h/day,12days).The protein expression levels of ASIC1a and ASIC1b were determined by immunohistochemical staining.Results ASIC1a and ASIC1b-positive immunoreactive neurons were observed in petrosal ganglions of normal rats.ASIC1a and AS... |
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| Keywords: | Petrosal ganglion Acid-sensing ion channels Chronic hypoxia |
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