首页 | 本学科首页   官方微博 | 高级检索  
检索        

尿微量蛋白检测对早期糖尿病肾病诊断的意义
引用本文:马昌军.尿微量蛋白检测对早期糖尿病肾病诊断的意义[J].西部医学,2008,20(2):282-283.
作者姓名:马昌军
作者单位:巴中市人民医院内分泌科,四川,巴中,636000
摘    要:目的探讨尿微量蛋白测定在糖尿病肾病(DN)早期诊断的意义。方法用RIA法分别测定95例早期DN患者(以尿白蛋白排泄率持续20-200μg/min为标准诊断,患者组A),80例无DN的糖尿病患者(患者组B)和82例正常健康人(对照组晨尿中的微量白蛋白(Micro—albumin,mAlb)、β2-微球蛋白(β2-microglobulin,β2-m)和α1-微球蛋白(α1-microglobulin,α1-m)的水平。结果患者组A与患者组B及对照组比较,各项检测指标均增高,而患者组B与对照组均相近。结论DN早期肾损害与尿微量蛋白密切相关,尿mAlb、β2-m和α1-m是反映早期DN的敏感指标。

关 键 词:早期糖尿病肾病  微量白蛋白  β2-微球蛋白  α1-微球蛋白
文章编号:1672-3511(2008)02-0282-02
修稿时间:2007年8月1日

Clinical significance of micro-amount of urinary proteins detection for patients with early diabetic nephropathy
MA Chang-jun.Clinical significance of micro-amount of urinary proteins detection for patients with early diabetic nephropathy[J].Medical Journal of West China,2008,20(2):282-283.
Authors:MA Chang-jun
Institution:MA Chang-jun (Department of Endocrinology ,Bazhong People' s Hospital, Bazhong 636000, Sichuan, China)
Abstract:Objective To investigate the diagnostic significance of mlcro-amount of urinary proteins detection in patients with early diabetic nephropathy. Methods Urinary mlcro-amount of albumin (MA) and β2-mieroglobulin(β2- m) ,α1-microglobulin, (α1-m)contents were measured by radioimmunoassay in: (1) Group A,95 type 2 diabetes mellitus (DM-2) patients with early DN (urinary albumin excretion rate : 20-200 μg/min) (2) Group B 80 DM -2 patients without DN and (3) 82 controls. Results Urinary contents of all these three kinds of proteins in Group A were significantly higher than those in Group B and controls(P〈0. 05). However, the contents in Group B were similar with controls. Conclusion Urinary MA, β2-m and α1-m are sensitive markers for detecting early DN.
Keywords:Early phase diabetic nephropathy  Micro-albumin  β2-microglobulin  α1-microglobulin
本文献已被 维普 万方数据 等数据库收录!
点击此处可从《西部医学》浏览原始摘要信息
点击此处可从《西部医学》下载免费的PDF全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号