| 煤焦沥青接触者血清SOD、MDA及唾液酸检测 |
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| 引用本文： | 张俊平,张巧,周舫,马永志,李时恩,李志远,赵一波.煤焦沥青接触者血清SOD、MDA及唾液酸检测[J].郑州大学学报(医学版),2006,41(2):374-375. |
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| 作者姓名： | 张俊平 张巧 周舫 马永志 李时恩 李志远 赵一波 |
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| 作者单位： | 1. 安阳市职业病防治所,安阳,455000
2. 郑州大学公共卫生学院劳动卫生学教研室,郑州,450052 |
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| 摘 要： | 目的:检测煤焦沥青接触者血清超氧化物歧化酶总量(SOD)、丙二醛(MDA)及唾液酸(SA)水平,探讨职业性肺癌的早期预警指标.方法:焦炉工55人(接触组),某高校教师、学生及职工40人(非接触组),采用硫代巴比妥酸法测定其血清MDA水平,采用黄嘌呤氧化快速比色法测定T-SOD水平,采用比色法测定SA水平.结果:接触组血清MDA、SA含量高于非接触组(P＜0.001),血清T-SOD含量低于非接触组(P＜0.001).接触组不同年龄及工龄组之间各指标差异均无统计学意义(P＞0.05).结论:煤焦沥青可导致接触者生物膜的明显损伤.SOD、MDA、SA等指标可用于职业性肺癌的早期预警.
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| 关 键 词： | 煤焦沥青 血清 MDA SA SOD 生物膜损伤 |
| 收稿时间： | 2004-08-06 |
| 修稿时间： | 2004年8月6日 |
Detection of serum SOD, MDA, and SA in workers exposed to coal tar pitch |
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| ZHANG Junping,ZHANG Qiao,ZHOU Fang,MA Yongzhi,LI Shi'en,LI Zhiyuan,ZHAO Yibo.Detection of serum SOD, MDA, and SA in workers exposed to coal tar pitch[J].Journal of Zhengzhou University: Med Sci,2006,41(2):374-375. |
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| Authors: | ZHANG Junping ZHANG Qiao ZHOU Fang MA Yongzhi LI Shi'en LI Zhiyuan ZHAO Yibo |
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| Institution: | 1.Anyang Institute of Occupational Disease Prevention and Cure ,Anyang 455000; 2 .Department of Labor Health, College of Public Health, Zhengzhou University, Zhengzhou 450052 |
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| Abstract: | Aim: To explore early monitoring index of occupational lung cancer. Methods: Serum levels of MDA,total SOD (T-SOD) and SA of 55 coke oven workers(exposure group) and 40 controls (unexposure group) were determined. Results: Compared with that of unexposure group, the serum levels of MDA and SA of exposure group were significantly higher(P<0.001), and the T-SOD levels were significantly lower(P<0.001). There were no significant differences in the above parameters between different ages and different working ages in exposure group(P>0.05). Conclusion: Coal tar pitch can result in obvious biomembrane damage of the exposed workers. Indexes such as MDA,T-SOD and SA can be used to alarm occupational lung cancer at early stage. |
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| Keywords: | coal tar pitch serum MDA SA SOD biomembrane damage |
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