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枸杞多糖对动脉粥样硬化模型兔血脂、脂质过氧化、NO和C-反应蛋白的影响
引用本文:马灵筠,陈群力,杨五彪,席守民,万学东,唐晓明,余燕妮,康健.枸杞多糖对动脉粥样硬化模型兔血脂、脂质过氧化、NO和C-反应蛋白的影响[J].郑州大学学报(医学版),2005,40(2):328-330.
作者姓名:马灵筠  陈群力  杨五彪  席守民  万学东  唐晓明  余燕妮  康健
作者单位:河南科技大学医学院生物化学与分子生物学教研室,洛阳,471003
基金项目:洛阳市科委基金资助项目 030724
摘    要:目的:探讨枸杞多糖对新西兰兔动脉粥样硬化的预防作用及其机制。方法:36只雄性新西兰兔随机分 为3组,每组12只。对照组喂普通饲料,模型组采用普通饲料加质量分数1.5%的胆固醇喂养,枸杞多糖(LBP)组 采用普通饲料加质量分数1.5%的胆固醇喂养,同时腹腔注射LBP(3.0mg/kg),10周后,测定各组空腹血清三酯酰 甘油(TG)、总胆固醇(TCh)、高密度脂蛋白胆固醇(HDL- C)、一氧化氮(NO)、丙二醛(MDA)、C -反应蛋白(CRP)含 量以及超氧化物歧化酶(SOD)活性,计算主动脉内膜粥样斑块面积并观察主动脉形态学变化。结果:模型组与对照 组比较,TG、TCh、NO、MDA、CRP升高(P<0.01),HDL- C/TCh、SOD活性下降(P<0.01),主动脉内膜粥样斑块面积 较大(P<0.01);LBP组与模型组比较,TG、NO、MDA、CRP下降(P<0.01或0.05),HDL -C/TCh、SOD活性升高 (P<0.01),主动脉内膜粥样斑块面积明显减少(P<0.05)。结论:枸杞多糖对动脉粥样硬化有明显的预防和治疗 作用,可能与其抗氧化、免疫调节、提高HDL- C/TCh有关。

关 键 词:动脉粥样硬化  枸杞多糖  抗氧化  血脂  一氧化氮  C-反应蛋白  家兔
修稿时间:2004年10月29

Effect of lycium barbarum polysaccharide against atherosclerosis in rabbits
MA Lingjun,CHEN Qunli,YANG Wubiao,XI Shoumin,WAN Xuedong,TANG Xiaoming,YU Yanni,KANG Jian.Effect of lycium barbarum polysaccharide against atherosclerosis in rabbits[J].Journal of Zhengzhou University: Med Sci,2005,40(2):328-330.
Authors:MA Lingjun  CHEN Qunli  YANG Wubiao  XI Shoumin  WAN Xuedong  TANG Xiaoming  YU Yanni  KANG Jian
Institution:MA Lingjun,CHEN Qunli,YANG Wubiao,XI Shoumin,WAN Xuedong,TANG Xiaoming,YU Yanni,KANG Jian Department of Biochemistry and Molecular Biology,Medical College,Henan University of Science and Technology,Luoyang 471003
Abstract:Aim: To study the effect and mechanism of lycium barbarum polysaccharide(LBP) against atherosclerosis in rabbits. Methods: Thirty-six healthy New Zealand white rabbits were randomly divided into three groups.Control group was fed with normal food,model group was fed with 1.5% cholesterol,and LBP group, 1.5% cholesterol plus 3.0 mg/kg LBP celiac injection. After ten weeks,the concentrations of triglyceride(TG),total cholesterol,high density lipoprotein cholesterol(HDL-C),C reactive protein(CRP),nitric oxide(NO),MDA,and the activity of SOD of each group were measured. Results: Compared with the control group,concentrations of TG,TCh,NO,MDA,and CRP of model group increased significantly(P<0.01),and activity of SOD and HDL-C/TCh decreased(P<0.01). Compared with the model group,concentrations of TG,NO,MDA,and CRP of LBP group significantly lowered(P<0.01 or 0.05), while the activity of SOD and HDL-C/TCh increased(P<0.01). Conclusion: LBP can effectively increase the activity of SOD against oxidation,regulate immunity,and elevate the radio of HDL-C/TCh.LBP is a potential drug in treating and preventing atherosclerosis.
Keywords:atherosclerosis  lycium barbarum polysaccharide  anti-oxidation  blood lipids  NO  C reactive protein  rabbit
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