湖北地区肠球菌耐药性观察

目的：分析临床分离肠球菌对抗菌药物的耐药性。方法：对湖北地区11所医院1998年10月～1999年9月临床分离肠球菌进行K-B药敏试验，用WHONET-4软件完成数据分析。结果：254株肠球菌中，粪肠球菌183株(72．0％)，屎肠球菌38株(14．9％)；肠球菌主要来自中段尿，其次为伤口、呼吸道、穿刺引流液。庆大霉素高耐株、链霉素高耐株分离率分别为47．3％和56．0％，耐万古霉素肠球菌分离率5．3％。粪肠球菌对庆大霉素、氯霉素、四环素、红霉素、克林霉素的耐药率均大于60％，屎肠球菌对β-内酰胺类相对耐药，对庆大霉素、四环素、红霉素、环丙沙星的耐药率为51．6％～92．3％。结论：肠球菌耐药尤其多重耐药严重。

Observation to the antimicrobial resistance of enterococci in HubeiProvince

Aim: To investigate the antimicrobial resistance of chnical isolates in enterococci. Mmethods: Susceptibility testwas carried out by using Kirby-Bauer method. A WHONET-4 computer software was used to analyse the data. Results: Enterococ-cus faecahs(efa) and enterococcus faecium(efm) occupied respectively 183 strains(72.0%) and 38 strains (14.9%) of 254strains entrococci. Enterococcus. came fiom urine mainly, others from wound, respiratory tract and drainage fluid in order. Detectionrates of high-level gentamycin resistance and high-level streptomycin resistance were 47.3 % and 56.0% individually, the rate ofvancomycin-resistant enterococci was 5.3 %. The percentage of resistance to gentamycin, chloromycin , tetracycline , erythromythinand chndamycin of efa was over 60% ;the rates of erin to gentamycin, tetracycline, erythromycin and ciprofloxacin from 51.6 % to92.3% ,erim were more resistant to β-lactam antibiotics than efa. Conclusion: Infections of enterococci especially multi-drug resis-tant bacteria were serious.