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缺血性脑血管病患者蛋氨酸合成酶基因A2756G多态性检测
引用本文:宋波,李艾帆,郑红,连建华,张世峰,贺颖,齐华,王茜,许予明.缺血性脑血管病患者蛋氨酸合成酶基因A2756G多态性检测[J].郑州大学学报(医学版),2007,42(3):436-438.
作者姓名:宋波  李艾帆  郑红  连建华  张世峰  贺颖  齐华  王茜  许予明
作者单位:1. 郑州大学第一附属医院神经内科,郑州,450052
2. 郑州大学基础医学院细胞生物学与医学遗传学教研室,郑州,450001
基金项目:河南省高等学校杰出人才创新工程项目 , 河南省杰出青年科学基金 , 河南省高校青年骨干教师资助项目
摘    要:目的:检测缺血性脑血管病患者蛋氨酸合成酶(MS)基因A2756G多态性.方法:运用PCR-限制性片段长度多态性(RFLP)技术对512例缺血性脑血管病患者及500例健康对照者进行MS基因多态性检测.结果:缺血性脑血管病患者组MS A2756G A/A、A/G、G/G基因型频率分别为88.9%、10.7%和0.4%,A和G等位基因频率分别为94.2%和5.8%.对照组A/A、A/G、G/G基因型频率分别为84.6%、15.0%和0.4%,A和G等位基因频率分别为92.1%和7.9%.2组基因型及等位基因频率差异均无统计学意义(P>0.05).结论:MS基因A2756G多态可能不足以构成河南汉族人群缺血性脑血管病发病中的一个独立的遗传危险因子.

关 键 词:缺血性脑血管病  蛋氨酸合成酶  基因多态性
收稿时间:2006-11-18
修稿时间:2006-11-18

Detection of methionine synthase gene A2756G polymorphisms in patients with ischemic cerebrovascular disease
SONG Bo,LI Aifan,ZHENG Hong,LIAN Jianhua,ZHANG Shifeng,HE Ying,QI Hua,WANG Qian,XU Yuming.Detection of methionine synthase gene A2756G polymorphisms in patients with ischemic cerebrovascular disease[J].Journal of Zhengzhou University: Med Sci,2007,42(3):436-438.
Authors:SONG Bo  LI Aifan  ZHENG Hong  LIAN Jianhua  ZHANG Shifeng  HE Ying  QI Hua  WANG Qian  XU Yuming
Institution:1 Department of Neurology, the First Affiliated Hospital, Zhengzhou University ,Zhengzhou 450052 ;2 Department of Cell Biology and Medical Genetics, College of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001
Abstract:Aim: To explore the relationship between methionine synthase (MS) gene A2756G polymorphism and ischemic cerebrovascular disease.Methods:The polymorphism of MS A2756G of 512 patients with ischemic cerebrovascular disease (patient group) and 500 healthy subjects (control group) was detected using PCR-RFLP.Results: In patient group, the frequencies of MS A2756G A/A,A/G,G/G genotypes were 88.9%,10.7% and 0.4%, and A and G allele frequencies were 94.2% and 5.8%. In the control group, the frequencies of MS A2756G A/A,A/G,G/G genotypes were 84.6%,15.0% and 0.4%, and A and G allele frequencies were 92.1% and 7.9%. There were no significant differences in the frequencies of genotypes or alleles between the two groups(P>0.05). Conclusion: MS gene A2756G polymorphism may not be an independent risk factor for ischemic cerebrovascular disease in Henan Han population.
Keywords:ischemic cerebrovascular disease  methionine synthase  polymorphism
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