肝硬化患者心输出量与血清一氧化氮含量测定

目的：了解肝硬化患者心输出量、平均动脉压与血清一氧化氮（ＮＯ）的变化，并探讨肝硬化患者心输出量与ＮＯ之间的关系。方法：用彩超及水银血压计分别检测１５ 例肝硬化患者及１０ 例正常人每分心输出量与平均动脉压的变化，Ｇｒｉｅｓｓ 方法测定５０ 例肝硬化患者及３０ 例正常人血清ＮＯ水平。结果：肝硬化患者与正常人比较，其每分心输出量增加（ Ｐ＜ ０－０２５） ，平均动脉压降低（ Ｐ＜０－０５），血清ＮＯ水平明显升高（ Ｐ＜ ０－００１） ，且肝硬化患者每分心输出量与血清ＮＯ水平呈正相关（ｒ＝０－６８，Ｐ＜０－０１） 。结论：肝硬化患者心输出量增加，说明肝硬化时机体存在着高动力循环，ＮＯ作为扩血管剂可能参与了其高动力循环的发病

Measurement of cardiac output and serum nitric oxide in patients with cirrhosis

Aim: To investigate the change of the cardiac output, mean arterial pressure and serum nitraic oxide in patients with cirrhosis, and to discuss the relationship between the cardiac output and nitric oxide in cirrhotic patients.Methods: The cardiac output and mean arterial pressure were measured in 15 cirrhotic patients and 10 normal controls by color ultrasound and mercurial sphygmomanometer, respectively. The level of serum nitric oxide was detected in 50 cirrhotic patients and 30 normal controls by Griess method. Results: Comparing with control, the cardiac output in patients with cirrhosis increased( P <0 025),and the mean arterial pressure decreased( P <0 05). The serum nitric oxide level in cirrhosis group was significantly higher ( P <0 001) than that of control,and showed a positive correlation with the cardiat output in cirrhotic patients ( r =0 68, P <0 01). Conclusion: The cardiac output in cirrhotic patients increased, which suggests that there is a hyperdynamic circulation in cirrhotic patients. Nitric oxide is a vasodilator which may relate to the pathogenesis of the hyperdynamic circulation in cirrhosis.