| 食管鳞癌组织中Syndecan-1蛋白及mRNA表达 |
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| 引用本文： | 曹学全,张红,娄欣,孙淼淼,高冬玲,张岚,宋一民,陈奎生.食管鳞癌组织中Syndecan-1蛋白及mRNA表达[J].郑州大学学报(医学版),2007,42(1):1-4. |
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| 作者姓名： | 曹学全 张红 娄欣 孙淼淼 高冬玲 张岚 宋一民 陈奎生 |
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| 作者单位： | 郑州大学第一附属医院病理科,河南省肿瘤病理重点实验室,郑州,450052 |
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| 摘 要： | 目的:检测食管鳞癌组织中Syndecan-1蛋白及mRNA的表达.方法:应用免疫组化SP法和原位杂交方法检测49例食管鳞癌组织及其相应的30例癌旁不典型增生组织和49例正常食管黏膜组织中Syndecan-1蛋白及其mRNA的表达.结果:①正常食管黏膜组织中Syndecan-1蛋白和mRNA均为阳性表达.食管鳞癌组织中Syndecan-1蛋白及mRNA阳性表达率均低于癌旁不典型增生组织和正常食管黏膜组织(P均＜0.05).②淋巴结转移者食管鳞癌组织与不典型增生组织中Syndecan-1蛋白和mRNA阳性表达率均低于无淋巴结转移组(P均＜0.05).③浸润至外膜的食管鳞癌组织及不典型增生组织中Syndecan-1蛋白和mRNA的阳性表达率分别低于深肌层及浅肌层(P均＜0.05).结论:人食管鳞癌组织中Syndecan-1蛋白及mRNA均呈低表达,Syndecan-1与食管鳞癌的发生发展及浸润转移有关.
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| 关 键 词： | 食管肿瘤 鳞状细胞癌 Syndecan-1 浸润 转移 |
| 收稿时间： | 2006-05-26 |
| 修稿时间： | 2006-05-26 |
Expression of Syndecan-1 protein and mRNA in esophageal squamous cell carcinoma tissue |
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| CAO Xuequan,ZHANG Hong,LOU Xin,SUN Miaomiao,GAO Dongling,ZHANG Lan,SONG Yimin,CHEN Kuisheng.Expression of Syndecan-1 protein and mRNA in esophageal squamous cell carcinoma tissue[J].Journal of Zhengzhou University: Med Sci,2007,42(1):1-4. |
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| Authors: | CAO Xuequan ZHANG Hong LOU Xin SUN Miaomiao GAO Dongling ZHANG Lan SONG Yimin CHEN Kuisheng |
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| Institution: | Department of Pathology, the First Affiliated Hospital, Zhengzhou University; Henan Key Laboratory of Tumor Pathology, Zhengzhou 450052 |
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| Abstract: | Aim: To detect the expression of Syndecan-1 protein and mRNA in esophageal squamous cell carcinoma(ESCC) tissue.Methods:The expressions of Syndecan-1 protein and mRNA in 49 cases of ESCC, 30 cases of adjacent atypical hyperplasia tissue and 49 cases of normal tissue were detected using immunohistochemistry and in situ hybridization.Results: The expressions of Syndecan-1 protein and mRNA were positive in normal esophageal mucosa. The posive rate of Syndecan-1 protein and mRNA in ESCC tissue was significantly lower than those of atypical hyperplasia tissue (P<0.05); in metastatic group, the positive rates of Syndecan-1 protein and mRNA in ESCC tissue and atypical hyperplasia tissue were lower than those in non-metastatic group (P<0.05); the positive rates of Syndecan-1 protein and mRNA in ESCC tissue and atypical hyperplasia tissue in outer layer invaded group were lower than those in superficial-muscle invaded group and deep-muscle invaded group (P<0.05). Conclusion: The expression of Syndecan-1 protein and mRNA in human ESCC tissue is decreased. Syndecan-1 is related to development, invasion and metastasis of ESCC. |
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| Keywords: | esophageal neoplasm squamous cell carcinoma Syndecan-1 invasion metastasis |
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