| 散发性卵巢癌组织中BRCA1蛋白的表达 |
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| 引用本文： | 史惠蓉,荆建红,赵先兰,韩丽萍,常青,郭燕燕.散发性卵巢癌组织中BRCA1蛋白的表达[J].郑州大学学报(医学版),2002,37(6):797-799. |
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| 作者姓名： | 史惠蓉 荆建红 赵先兰 韩丽萍 常青 郭燕燕 |
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| 作者单位： | 1. 郑州大学第一附属医院妇产科,郑州,450052
2. 北京大学第一临床医院妇产科,北京,100034 |
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| 基金项目： | 河南省科技攻关基金资助项目 981170 2 2 2 |
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| 摘 要： | 目的：探讨散发性卵巢癌组织中BRCA1蛋白的表达及其意义。方法：用免疫组织化学方法检测43例散发性卵巢上皮性癌（OEC）、10例交界性卵巢上皮性肿瘤和14例良性卵巢上皮性肿瘤中BRCA1蛋白的表达。结果：OEC组织中BRCA1的阳性表达率为39．5％（17／43），交界性卵巢上皮性肿瘤组织中为90．0％（9／10），良性卵巢上皮性肿瘤组织中为92．8％（13／14）。OEC组织中BRCA1蛋白表达阳性率显著低于良性卵巢上皮性肿瘤和交界性卵巢上皮性肿瘤（P＜0．005）。结论：BRCA1蛋白表达降低在散发性卵巢癌的发病过程中可能具有重要作用。
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| 关 键 词： | 散发性卵巢癌 BRCA1蛋白 免疫组织化学 |
| 修稿时间： | 2001年11月19 |
Expression of BRCA1 protein in sporadic ovarian cancer |
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| SHI Huirong ,JING Jianhong ,ZHAO Xianlan ,Han Liping ,CHANG Qing ,GUO Yanyan.Expression of BRCA1 protein in sporadic ovarian cancer[J].Journal of Zhengzhou University: Med Sci,2002,37(6):797-799. |
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| Authors: | SHI Huirong JING Jianhong ZHAO Xianlan Han Liping CHANG Qing GUO Yanyan |
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| Institution: | SHI Huirong 1),JING Jianhong 1),ZHAO Xianlan 1),Han Liping 1),CHANG Qing 1),GUO Yanyan 2) 1) Department of Obstetrics and Gynecology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052 2) Department of Obstetrics and Gynecology,the First Hospital,Beijing University,Beijing 100034 |
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| Abstract: | Aim: To investigate the expression of BRCA1 protein in sporadic ovarian cancer and its significance. Methods: The expression of BRCA1 protein in 43 cases of sporadic ovarian cancer,10 cases of borderline epithelial ovarian tumor,and 14 cases of benign epithelial ovarian tumor were detected by immunohistochemistry. Results: BRCA1 positive expression rates were 39.5%(17/43) in sporadic ovarian cancers,90.0%(9/10) in borderline epithelial ovarian tumor, and 92.8%(13/14) in benign epithelial ovarian tumor respectively. The positive expression rate of BRCA1 protein in sporadic ovarian cancers was lower than those in benign and borderline epithelial ovarian tumors ( P <0.005). Conclusion: The reduction of BRCA1 expression may play an important role in the carcinogenesis of sporadic ovarian cancer. |
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| Keywords: | ovarian neoplasm BRCA1 immunohistochemistry |
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