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| 胃癌组织中骨桥蛋白与尿激酶型纤溶酶原激活物的表达 | |
| 引用本文： | 赵治国,周明锴,秦胜利,李振锋,张献东,崔静,常卫华.胃癌组织中骨桥蛋白与尿激酶型纤溶酶原激活物的表达[J].郑州大学学报(医学版),2007,42(5):906-908. |
| 作者姓名： | 赵治国 周明锴 秦胜利 李振锋 张献东 崔静 常卫华 |
| 作者单位： | 1. 郑州大学第二附属医院消化内科,郑州,450014 2. 信阳市中心医院普外科,信阳,464000 3. 漯河郾城区中心医院内科,漯河,462300 4. 河源市中心医院消化内科,河源,517000 |
| 摘 要： | 目的:探讨胃癌组织中骨桥蛋白(OPN)与尿激酶型纤溶酶原激活剂(uPA)的表达及二者的表达与胃癌侵袭、转移间的关系.方法:应用免疫组织化学方法检测67例进展期胃癌组织、20例癌旁正常组织中OPN与uPA蛋白的表达.结果:67例胃癌组织中OPN与uPA蛋白的阳性表达率分别为70.1%(47/67)、64.2%(43/67).OPN与uPA 的表达与肿瘤组织类型、临床病理分期、浸润深度、淋巴结转移程度及有无远处转移有关(P＜0.05),与患者年龄、性别及肿瘤的分化程度无关(P＞0.05).胃癌组织中OPN与uPA蛋白的表达呈正相关(rs＝0.669,P＜0.05).结论:OPN、uPA蛋白与胃癌侵袭转移密切相关,能够作为反映肿瘤的生物学特性及评估预后的重要参考指标. |
| 关 键 词： | 骨桥蛋白 尿激酶型纤溶酶原激活物 胃肿瘤 侵袭转移 |
| 修稿时间： | 2006-09-13 |
Expression of osteopontin and uPA in gastric carcinoma tissue |
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| ZHAO Zhiguo,ZHOU Mingkai,QIN Shengli,LI Zhenfeng,ZHANG Xiandong,CUI Jing,CHANG Weihua.Expression of osteopontin and uPA in gastric carcinoma tissue[J].Journal of Zhengzhou University: Med Sci,2007,42(5):906-908. | |
| Authors: | ZHAO Zhiguo ZHOU Mingkai QIN Shengli LI Zhenfeng ZHANG Xiandong CUI Jing CHANG Weihua |
| Institution: | 1 Department of Gastroenterology, the Second Affiliated Hospital, Zhengzhou University, Zhengzhou 450014 ;2 Department of General Surgery, the Central Hospital of Xinyang, Xinyang 464000 ;3 Department of Internal Medicine,the Central Hospital of Yancheng , Luohe 462300 ;4 Department of Gastroenterology, the Central Hospital of Heyuan, Heyuan 517000 |
| Abstract: | Aim:To investigate the expressions of osteopontin(OPN) and urokinase-type plasminogen activator(uPA) and their relation to the invasiveness and metastasis of gastric carcinoma.Methods:The expression of OPN and uPA in 67 cases of gastric carcinoma tissue and 20 cases of adjacent normal tissue was detected using immunohistochemistry method.Results:In gastric cancer tissue,the positive expression rates of OPN and uPA were 70.1%(47/67) and 64.2%(43/67),respectively.The expression of OPN and uPA was related to histological type,pathological stage,invasion depth,lymphatic and distant metastasis(P<0.05),but not related to age,sex or differentiation degree(P>0.05).The expression of OPN was positively correlated with that of uPA in gastric carcinoma tissue(rs=0.669,P<0.05).Conclusion:Both OPN and uPA are significantly related to the invasiveness and metastasis of gastric carcinoma.The expression of them can reflect the biological characteristics of gastric carcinoma and could be used as important indicator in prognosis of gastric carcinoma. |
| Keywords: | osteopontin uPA gastric neoplasm invasiveness and matastasis |
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