| CC趋化因子受体4及其抑制剂研究进展 |
| |
| 引用本文： | 孙朝晖,魏菊.CC趋化因子受体4及其抑制剂研究进展[J].国际药学研究杂志,2010,37(1):29-31. |
| |
| 作者姓名： | 孙朝晖 魏菊 |
| |
| 作者单位： | 1. 赤峰学院附属医院药剂科,赤峰,024000
2. 河南省方城县中医院,南阳,473200 |
| |
| 摘 要： | CC趋化因子受体4（CCR4）是G蛋白偶联受体家族成员之一，由包含7次跨膜结构域的多肽链组成，表达于多种细胞或组织中。CCR4通过与其内源性配体CCL17、CCL22及CKLF1作用介导多种炎症反应，尤其在哮喘发生和发展的病理过程中起重要作用，因此可能是某些炎性疾病、特别是哮喘的潜在治疗靶点。本文对CCR4及其抑制剂的研究进展做一综述。
|
| 关 键 词： | 趋化因子 CC 受体 趋化因子 拮抗剂 受体 G蛋白偶联 自身免疫性疾病 哮喘 |
| 收稿时间： | 2009-12-22 |
| 修稿时间： | 2010-1-11 |
CC chemokine receptor 4 and its inhibitors: research advances |
| |
| SUN Zhao-hui, WE Ju.CC chemokine receptor 4 and its inhibitors: research advances[J].Foreign Medical Sciences(Section of Pharmarcy),2010,37(1):29-31. |
| |
| Authors: | SUN Zhao-hui WE Ju |
| |
| Institution: | <SPAN style= |
| |
| Abstract: | CC chemokine receptor 4(CCR4)，a member of G protein coupled receptor family, is consisted of a polypeptide chain containing seven transmembrane domains and expressed on various cells and tissues.CCR4 can mediate inflammatory reaction by interacting with its ligands such as CCL17,CCL22 and CKLF1,which especially plays an important role in occurrence and development of asthma, thus it could be a potential target for treating inflammatory diseases, especially for asthma. In this paper，the research progress of CCR4 and its inhibitors is summarized. |
| |
| Keywords: | chemokine CC receptor chemokine antagonist receptor G protein coupled autoimmne diseases asthma |
| 本文献已被 维普 万方数据 等数据库收录！ |
| 点击此处可从《国际药学研究杂志》浏览原始摘要信息 |
| 点击此处可从《国际药学研究杂志》下载免费的PDF全文 |
