抗肿瘤药物脂质体粒径对肿瘤靶向性的影响

脂质体抗癌药物的粒径在它将药物运载到肿瘤组织的过程中是一个重要的因素。在本文中，脂质体粒径在药代动力学中所发挥的作用从以下几方面进行了研究：（1）脂质体在血液中的分布和滞留时间；（2）脂质体在肿瘤组织中的积聚；（3）脂质体从肿瘤毛细血管中渗漏和它们在肿瘤组织中的滞留。最后，讨论了脂质体粒径在设计抗肿瘤脂质体药物时的重要性。

The size of liposomes: a factor which affects their targeting efficiency to tumors

The size of liposomes has been shown to be an important factor in the efficient delivery of an antitumor agent to tumors. In this paper, the effects of the size of liposomes on the pharmacokinetics of liposomes and liposome encapsulated drugs are discussed with reference to: (1) the circulation amount and residence time of liposomes in the blood; (2) the accumulation of liposomes in the tumor; (3) permeation of liposomes through tumor capillaries and their retention in tumor tissue. Finally the importance of the size of liposome in the design of an effective liposomal antitumor preparation is discussed.