| The Influences of Electroacupuncture on the Quantitative Changes of Ultra Structure in CA3 Sector of the Hippocampus of VD Rats |
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| 作者姓名： | XU Neng-gui TANG Chun-zhi YAN Bing |
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| 作者单位： | School of Preventive Medicine, Guangzhou University of TCM, Guangzhou 510405 |
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| 基金项目： | Acknowledgements： The Quantitative Changes of Ultra Structure was a generous gift by professor XU Neng-gui, Department of Scientific Research of Guangzhou University of TCM. This research work was supported by the Ministry of National Education plans for the training of the new century talents （No. NCET-04-0831）. |
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| 摘 要： | Objective To observe the effect of electroacupuncture （EA） on learning and memory and the pathology morphologic of nerve and the quantitative changes of synapses in CA3 sector of the hippocampus on vascular dementia （VD） rats. Methods The VD rats were modeled with method of global ischemia reperfusion by 4 vascular occlusion （4-vo）. Morris water maze tests were used for a behavioral study. The changes of the ultra structure parameter in CA3 sector of the hippocampus were studied with transmission electron microscope and picture analysis system. Results The model group animals needed more escape time than the control group, and they did not swim longer in platform quadrant than in the others in the Morris water tests. In the control group and electro-acupuncture group, the modality configuration of cells in CA3 sector of the hippocampus was normal, and the normal and abnormal chromatin was obvious. The configuration of endoplasmic reticulum, chondriosome and synapses was normal. The front and back membrane of the synapses was clear. In the VD group, the cells were atrophied and dwindled. The front and back membrane of the synapses was illegible. The clearance, PSD and interphase curvature on area of Gray type Ⅰ synapses in CA3 sector of the hippocampus in VD rats were decreased significantly. In the EA group, the animals cut the escape time mostly and they swam more times in platform quadrant than in other three quadrants. The interphase curvature, cleft and PSD on area of Gray type Ⅰ synapses in CA3 sector of the hippocampus were increased significantly. Conclusion EA can improve learning and memory of VD rats by restraining the disappearance of nerve cells, and influencing the structure parameter of synapses in CA3 sector of the hippocampus.
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| 关 键 词： | 电针刺 数量变化 海马 鼠 CA3扇区 血管性痴呆 突触 |
The Influences of Electroacupuncture on the Quantitative Changes of Ultra Structure in CA3 Sector of the Hippocampus of VD Rats |
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| XU Neng-gui TANG Chun-zhi YAN Bing.The Influences of Electroacupuncture on the Quantitative Changes of Ultra Structure in CA3 Sector of the Hippocampus of VD Rats[J].Journal of US-China Medical Science,2008,5(1):48-55. |
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| Authors: | XU Neng-gui TANG Chun-zhi YAN Bing |
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| Institution: | School of Preventive Medicine, Guangzhou University of TCM, Guangzhou 510405 |
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| Abstract: | electroacupuncture vascular dementia hippocampus synapse |
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| Keywords: | electroacupuncture vascular dementia hippocampus synapse |
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