针刺对脑卒中后抑郁模型大鼠行为学的影响

目的：观察分析针刺百会、风府、神门、太冲穴对脑卒中后抑郁（Post-stroke depression，PSD）模型大鼠行为学、神经功能缺损以及体重的影响，为针灸治疗脑卒中后抑郁（PSD）提供科学的依据。方法建立大脑中动脉线拴阻塞法（MCAO）模型复合慢性不可预知性应激抑郁症（CUMS）模型，观察各组大鼠体质量，敞箱实验以及糖水消耗实验的变化。结果治疗后针刺组及药物组大鼠与模型组大鼠的体质量以及行为学评估结果相比，均有明显增加（P＜0.05）；针刺组与药物组大鼠的体质量以及行为学评估结果相比，无差异（P＞0.05）。结论针刺百会、风府、神门、太冲穴与盐酸氟西汀在治疗脑卒中后抑郁大鼠中均有效，且疗效相当。

The Effects of Manipulating Needles Points on the Behaviors of the Rat Models with Post-stroke Depression

Objective By observation and analysis of the effects of manipulating needles in Baihui,Fengfu,Shenmen and Taichong points on the behaviors,neurological deficits and weights of the rat models with post-stroke depression,to provide scientific evidence for acupuncture of post-stroke depression. Methods Establishing of MCAO models and CUMS models in minds of rats,observing the weights of rats and the changed results of the open field tests and sucrose consumption tests. Results After the treatments,comparing to the results of rats in model group,the weights and the behavioural assessments of rats in acupuncture group and medical group increase markedly （P〈0. 05）;while the behavioural assessments of rats between acupuncture group and medical group are still same （P〉0. 05）. Conclusion Acupuncture of Baihui,Fengfu,Shenmen and Taichong points and Fluoxetine Hydrochloride are both have clinical efficacies,and the efficacies are equivalent.