| 重金属暴露秀丽线虫中存在咽泵运动与寿命之间的显著关联 |
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| 引用本文： | 杨燚超,邢晓娟,王大勇.重金属暴露秀丽线虫中存在咽泵运动与寿命之间的显著关联[J].东南大学学报(医学版),2010,29(1):10-16. |
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| 作者姓名： | 杨燚超 邢晓娟 王大勇 |
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| 作者单位： | 东南大学医学院,生物化学与分子生物学系、发育与疾病相关基因教育部重点实验室,江苏,南京,210009 |
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| 基金项目： | supported by the grants from the National Natural Science Foundation of China(No.30870810);;the Program for New Century Excellent Talents in University |
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| 摘 要： | 目的：分析重金属暴露秀丽线虫中咽泵运动与寿命之间的相关性。方法：毒性评估实验选择重金属Hg、Pb、Cr与Cd。分析重金属暴露秀丽线虫中咽泵运动的变化情况,并进一步利用线性回归方法分析重金属暴露秀丽线虫中咽泵运动与寿命之间的相关性。结果：在所有评价浓度下的Hg与Pb暴露以及100与200μmol.L-1浓度下的Cr与Cd暴露均可以显著降低咽泵的运动速率。咽泵运动速率的变化显著相关于秀丽线虫所暴露重金属的浓度。而且,重金属暴露秀丽线虫中的咽泵运动速率显著相关于动物的寿命长度。结论：重金属暴露秀丽线虫中存在咽泵运动速率与寿命长度之间的显著关联,且在分析环境有害物质的毒害时,其对于秀丽线虫寿命的毒害可以通过咽泵运动速率来间接进行评价。
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| 关 键 词： | 重金属 关联 咽泵运动 寿命 秀丽线虫 |
The close association of pharyngeal pumping with mean lifespan can be observed in metal exposed nematode Caenorhabditis elegans |
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| YANG Yi-chao,XING Xiao-juan,WANG Da-yong.The close association of pharyngeal pumping with mean lifespan can be observed in metal exposed nematode Caenorhabditis elegans[J].Journal of Southeast Univ: Medical Sci Ed,2010,29(1):10-16. |
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| Authors: | YANG Yi-chao XING Xiao-juan WANG Da-yong |
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| Institution: | Key Laboratory of Developmental Genes and Human Disease in Ministry of Education/a>;Department of Biochemistry and Molecular Biology/a>;Southeast University Medical School/a>;Nanjing 210009/a>;China |
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| Abstract: | Objective:To investigate the association of pharyngeal pumping with mean lifespan in metal exposed nematode Caenorhabditis elegans.Methods:The metals of Hg,Pb,Cr,and Cd were selected for toxicity assay.The alterations of pharyngeal pumping in metal exposed nematodes were examined.In addition,the association of pharyngeal pumping with mean lifespan in metal exposed nematodes was determined by linear regression method.Results:Exposure to Hg and Pb at all examined concentrations and to Cr and Cd at concentrati... |
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| Keywords: | heavy metal association pharyngeal pumping mean lifespan Caenorhabditis elegans |
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