| CT/MRI双模态造影剂的制备和表征 |
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| 引用本文： | 王月花,宋丽娜,丁佳丽,鲁珊珊,蒋燕妮,张宇,顾宁.CT/MRI双模态造影剂的制备和表征[J].东南大学学报(医学版),2011,30(5):671-675. |
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| 作者姓名： | 王月花 宋丽娜 丁佳丽 鲁珊珊 蒋燕妮 张宇 顾宁 |
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| 作者单位： | 1. 东南大学,生物科学与医学工程学院,生物电学国家重点实验室,江苏省生物材料与器件重点实验室,江苏,南京,210096
2. 江苏省人民医院,放射科,江苏,南京,210029 |
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| 基金项目： | 国家自然科学基金资助项目，国家重大科学研究计划项目 |
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| 摘 要： | 目的:合成用于CT/MRI双模态造影的水包油型纳米乳液,并对其进行表征。方法:用共沉淀法合成油酸包裹的Fe3O4纳米颗粒,然后将其分散到市售的碘化油注射液中,借助纳米乳液的合成方法合成出CT/MRI双模态造影剂,并用透射电镜(TEM)、动态光散射(DLS)、水平磁场作用下乳滴的组装、CT和MRI等方法进行表征。结果:(1)TEM结果显示,乳滴的直径约为100 nm,DLS测得其水动力尺寸平均为81.7 nm;(2)将乳液置于水平磁场作用下验证了Fe3O4纳米颗粒确实存在于乳滴内;(3)CT、MRI等分析手段显示了该乳液的CT值为292.6 HU(碘含量为24 mg.ml-1),弛豫率为65.7 mmol.L-1.s-1。结论:CT/MRI双模态造影的水包油型纳米乳液具有良好的CT和MRI造影增强效果,有望成为一种性能优异的CT/MRI双模态造影剂。
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| 关 键 词： | 体层摄影术 X线计算机 磁共振成像 双模态 Fe3O4纳米颗粒 纳米乳液 |
Synthesis and characterization of dual modality contrast agent for CT/MRI imaging |
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| WANG Yue-hua,SONG Li-na,DING Jia-li,LU Shan-shan,JIANG Yan-ni,ZHANG Yu,GU Ning.Synthesis and characterization of dual modality contrast agent for CT/MRI imaging[J].Journal of Southeast Univ: Medical Sci Ed,2011,30(5):671-675. |
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| Authors: | WANG Yue-hua SONG Li-na DING Jia-li LU Shan-shan JIANG Yan-ni ZHANG Yu GU Ning |
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| Institution: | WANG Yue-hua1,SONG Li-na1,DING Jia-li1,LU Shan-shan2,JIANG Yan-ni2,ZHANG Yu1,GU Ning1(1.State Key Laboratory of Bioelectronics and Jiangsu Laboratory for Biomaterials and Devices,Southeast University,Nanjing 210096,China,2.Department of Radiology,Jiangsu Province Hospital,Nanjing 210029,China) |
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| Abstract: | Objective: To synthesis a kind of oil-in-water nanoemulsion for dual modal CT/MRI imaging and characterize it.Methods: Using coprecipitation method to synthesis oleic acid coated Fe3O4 nanoparticles,and dispersed them into iodinated oil injection.CT/MRI dual modality contrast agent was prepared on the basis of nanoemulsion formation,which was characterized by TEM,DLS,assembly of nanodroplets under a horizontal magnetic field,CT and MRI.Results:(1) TEM results revealed that the nanoemulsion had a size of 100... |
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| Keywords: | tomography X-ray computed magnetic resonance imaging dual modality Fe3O4 nanoparticles nanoemulsion |
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