| 肿瘤热疗用磁性纳米颗粒制备及其聚集态对升温效果的影响 |
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| 引用本文： | 沈旭黎,宋孟杰,张宇,马明,顾宁.肿瘤热疗用磁性纳米颗粒制备及其聚集态对升温效果的影响[J].东南大学学报(医学版),2011,30(5):675-679. |
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| 作者姓名： | 沈旭黎 宋孟杰 张宇 马明 顾宁 |
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| 作者单位： | 东南大学,生物科学与医学工程学院,江苏省生物材料与器件重点实验室,生物电子学国家重点实验室,江苏,南京,210096 |
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| 基金项目： | 国家自然科学基金资助项目，国家重大科学研究计划资助项目 |
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| 摘 要： | 目的:获得高磁性的铁氧体纳米颗粒,使其升温效果达到最优,从而更有利于肿瘤磁热疗.方法:通过高温裂解法一步合成均匀稳定的Fe3O4纳米颗粒,将原料从FeCl2替换为MnCl2、ZnCl2可以进一步得到Mn-Zn铁氧体纳米颗粒.通过DMSA修饰替换掉原来颗粒表面的油酸,使之可以溶于水相.结果与讨论:Mn-Zn铁氧体纳米颗粒...
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| 关 键 词： | Fe3O4 MnZnFe2O4 聚集 升温效果 |
Preparation of magnetic nanoparticles for hyperthermia and the impact of aggregation state on heating effect |
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| SHEN Xu-li,SONG Meng-jie,ZHANG Yu,MA Ming,GU Ning.Preparation of magnetic nanoparticles for hyperthermia and the impact of aggregation state on heating effect[J].Journal of Southeast Univ: Medical Sci Ed,2011,30(5):675-679. |
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| Authors: | SHEN Xu-li SONG Meng-jie ZHANG Yu MA Ming GU Ning |
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| Institution: | SHEN Xu-li,SONG Meng-jie,ZHANG Yu,MA Ming,GU Ning(Institute of Biologic Science and Medical Engineering of Southeast University,Jiangsu Key Laboratory for Biomaterials and Devices,State Key Laboratory of Bioelectronics,Jiangsu 210096,China) |
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| Abstract: | Objective: To obtain high magnetic ferrite nanoparticles by metal ion doping,and adjust the aggregation state to optimize the heating effect,which is more conducive to tumor hyperthermia.Method: Uniform and stable Fe3O4 nanoparticles was synthesized by one-pot thermal decomposition method,Mn-Zn ferrite nanoparticles were then obtained by replacing raw material from FeCl2 to MnCl2,ZnCl2.DMSA was modified on the surface of particles to replace the original oleic acid,so the nanoparticales were soluble in wate... |
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| Keywords: | Fe3O4 MnZnFe2O4 aggregation heating effect |
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