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芬太尼透皮贴剂与美施康定控制中重度癌痛临床疗效比较
引用本文:张双捷,刘宝瑞,钱晓萍.芬太尼透皮贴剂与美施康定控制中重度癌痛临床疗效比较[J].东南大学学报(医学版),2004,23(5):317-319.
作者姓名:张双捷  刘宝瑞  钱晓萍
作者单位:南京市鼓楼医院,肿瘤科,江苏,南京,210008
摘    要:目的:比较芬太尼透皮贴剂(商品名为多瑞吉)与美施康定控制癌痛的疗效和副作用。方法:81例患者随机分为两组,多瑞吉组43例,美施康定组38例,分别就其疗效、生活质量改善情况以及不良反应等方面进行评价。结果:多瑞吉与美施康定治疗中重度癌痛的有效率分别为83.7%和81.6%。两组生活质量改善情况治疗前后均有差异,但便秘、恶心、呕吐、嗜睡等不良反应方面多瑞吉组明显低于美施康定组。结论:两药治疗中重度癌痛疗效可靠,生活质量均可得到改善,但多瑞吉不良反应发生率较低,可作为临床首选用药或口服吗啡替代药。

关 键 词:芬太尼透皮贴剂  美施康定  中重度癌痛  副作用
文章编号:1671-6264(2004)05-0317-03
修稿时间:2004年3月18日

A comparison between transdermal fentanyl and MS contin for the treatment of moderate or severe cancer pain
ZHANG Shuang-jie,LIU Bao-rui,QIAN Xiao-ping.A comparison between transdermal fentanyl and MS contin for the treatment of moderate or severe cancer pain[J].Journal of Southeast Univ: Medical Sci Ed,2004,23(5):317-319.
Authors:ZHANG Shuang-jie  LIU Bao-rui  QIAN Xiao-ping
Abstract:Objective To compare the efficacy, side-effects of transdermal fentanyl(Durogesic) and MS contin for the treatment of moderate or severe cancer pain. Methods 81 patients with moderate or severe cancer pain were randomly divided into two groups,46 in group Durogesic,51 in group MS contin.And then the efficacy, side-effects and life quality changes of the two groups were estimated.Results The pain remission rate of group Durogesic was 83.7% and that of group MS contin 81.6%. The quality of life improved markedly in both groups after the administration.But the adverse effects in group Durogesic were less than that in group MS contin.Conclusion The theraputic effects of the two drugs are stable,but the side-effects of Durogesic are mild.
Keywords:transdermal fentanyl  MS contin  cancer  pain
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