| 前列腺素E_1对兔急性心肌梗死再灌注后P-选择素及无复流的影响 |
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| 引用本文： | 曾璟,孙经武.前列腺素E_1对兔急性心肌梗死再灌注后P-选择素及无复流的影响[J].滨州医学院学报,2009,32(2). |
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| 作者姓名： | 曾璟 孙经武 |
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| 作者单位： | 滨州医学院附属医院心内科,滨州市,256603 |
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| 摘 要： | 目的 探讨兔急性心肌梗死再灌注后无复流现象与炎症的关系,评价前列地尔(前列腺素E1)对炎症的影响及对无复流的作用.方法 建立大白兔心肌缺血再灌注损伤动物模型,随机分为假手术组、对照组和前列地尔治疗组,免疫组织化学法观察心肌P-选择素(Ps)的变化,最后计算心肌梗死面积及无复流面积.结果 Ps免疫组化显示,对照组及治疗组中,Ps在复流区及无复流区血管内皮细胞有强表达,明显强于正常区及假手术组(P均＜0.01);无复流区表达强于复流区(P＜0.01).前列地尔治疗组与对照组比较,Ps在复流区及无复流区表达均明显减弱(P ＜0.01).病理染色分析示,前列地尔治疗组与对照组比较:结扎区面积差异无统计学意义(P＞0.05);无复流面积和坏死心肌面积均较对照组显著降低(P均＜0.01).结论 前列地尔(PGE1)能通过抑制炎症反应起到保护心肌,减少心肌梗死面积,减少无复流面积的作用.
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| 关 键 词： | 无复流 炎症反应 P-选择素 前列地尔 |
Effect of prostaglandin E_1(PGE_1)on P-selectin and no-reflow in a rabbit model of acute myocardial infarction and reperfusion |
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| ZENG Jing,SUN Jingwu.Effect of prostaglandin E_1(PGE_1)on P-selectin and no-reflow in a rabbit model of acute myocardial infarction and reperfusion[J].Journal of Binzhou Medical College,2009,32(2). |
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| Authors: | ZENG Jing SUN Jingwu |
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| Institution: | ZENG Jing SUN Jingwu Department of Cardiovascular Medicine,Affiliated Hospital of Binzhou Medical University,Binzhou 256603 |
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| Abstract: | Objective To investigate relationship between no-reflow phenomenon and inflammation in a rabbit model of acute myocardial infarction and reperfusion.To evaluate effects of prostaglandin E1 on inflammation and no-reflow phenomenon in a rabbit model of acute myocardial infarction and reperfusion.Methods Erect animal model of myocardium ischemia-reperfusion.To observe myocardial P-selectin(Ps) by immunohistochemical(IHC) method.The area of no-reflow was evaluated with pathological means.Necrosis area was measu... |
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| Keywords: | no-reflow inflammation P-selectin prostaglandin E1 |
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