| 山东籍汉族寻常型天疱疮与HLA-DRB1基因的相关性研究 |
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| 引用本文： | 周淑华,王秀敏,韩兆东,高昱,张玉杰,杨磊,张建明,王忠永.山东籍汉族寻常型天疱疮与HLA-DRB1基因的相关性研究[J].滨州医学院学报,2006,29(6):401-402,409. |
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| 作者姓名： | 周淑华 王秀敏 韩兆东 高昱 张玉杰 杨磊 张建明 王忠永 |
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| 作者单位： | 滨州医学院附属医院皮肤科,滨州市,256603;滨州医学院附属医院皮肤科,滨州市,256603;滨州医学院附属医院皮肤科,滨州市,256603;滨州医学院附属医院皮肤科,滨州市,256603;滨州医学院附属医院皮肤科,滨州市,256603;滨州医学院附属医院皮肤科,滨州市,256603;滨州医学院附属医院皮肤科,滨州市,256603;滨州医学院附属医院皮肤科,滨州市,256603 |
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| 摘 要： | 目的 探讨HLA-DRB1、DQB1位点基因在山东籍汉族寻常型天疱疮易感性中的作用.方法 用序列特异性引物聚合酶链反应(PCR-SSP)方法,对61例寻常型天疱疮(pemphigus vulgaris,PV)患者和57名正常对照者进行了HLA-DRB1、DQB1等位基因的分型,并分析了DRB1、DQB1基因在两组中的分布.结果 与正常对照组比较,PV患者组DRB1 *14(*1401、*1404、*1405)基因频率明显增高(Pc分别＜0.05).结论 HLA-DRB1*14是山东籍汉族PV的易感基因.
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| 关 键 词： | 天疱疮 寻常型 聚合酶链反应 HLA-DRB1 |
| 文章编号： | 1001-9510（2006）06-0401-03 |
| 收稿时间： | 2006-08-22 |
| 修稿时间： | 2006-08-22 |
Association between HLA-DRB1 genes and pemphigus vulgaris in Han Shandong Chinese |
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| ZHOU Shuhua ,WANG Xiumin ,HAN Zhaodong et al.Association between HLA-DRB1 genes and pemphigus vulgaris in Han Shandong Chinese[J].Journal of Binzhou Medical College,2006,29(6):401-402,409. |
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| Authors: | ZHOU Shuhua WANG Xiumin HAN Zhaodong |
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| Institution: | Department of Dermatology ,Affiliated Hospital of Binzhou Medical College, Binzhou 256603 |
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| Abstract: | Objective To investigate the predisposing role of HLA-DRB1 genes in pemphigus vulgaris(PV).Methods We used polymerase chain reaction-specific sequence primers method to type HLA-DRB1,DQB1 subregion in the patients with PV of Han nationality from Shandong Province and matched control subjects.Results The results demonstrated that DR4,DRB1*14(*1401,*1404,*1405)gene frequencies were significantly higher in PV than those in controls(Pc<0.05).Further typing of DR4 positive subjects revealed that the gene frequencies of DRB1*0406 were significantly in PV patients compared with controls(P<0.05).Conclusion The results suggested that HLA-DRB1*14 may be the susceptible haplotypes for PV patients in Chinese Han. |
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| Keywords: | pemphigus vulgaris PCR HLA-DRB1 HLA-DQB1 |
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